Bibliographic Details
| Title: |
Extracellular vesicles as potential diagnostic markers for kidney allograft rejection. |
| Authors: |
Thongwitokomarn, Harit, Noppakun, Kajohnsak, Chaiwarith, Romanee, Chattipakorn, Siriporn C., Chattipakorn, Nipon |
| Source: |
Clinical Transplantation; Apr2024, Vol. 38 Issue 4, p1-13, 13p |
| Subject Terms: |
GRAFT rejection, EXTRACELLULAR vesicles, CHRONIC kidney failure, KIDNEY transplantation, KIDNEYS, RENOVASCULAR hypertension |
| Abstract: |
Kidney transplantation is a highly effective treatment for end‐stage kidney disease. However, allograft rejection remains a significant clinical challenge in kidney transplant patients. Although kidney allograft biopsy is the gold‐standard diagnostic method, it is an invasive procedure. Since the current monitoring methods, including screening of serum creatinine and urinary protein, are not of sufficient sensitivity, there is a need for effective post‐transplant monitoring to detect allograft rejection at an early stage. Extracellular vesicles are vesicles with a lipid bilayer that originate from different cell types in pathological and physiological conditions. The content of extracellular vesicles reflects the status of cells at the time of their production. This review comprehensively summarizes clinical, in vivo, and in vitro reports that highlight the potential of extracellular vesicles as diagnostic biomarkers for kidney allograft rejection. Clarification would facilitate differentiation between rejection and non‐rejection and identification of the mechanisms involved in the allograft rejection. Despite increasing evidence, further research is necessary to establish the clinical utility of extracellular vesicles in the diagnosis and monitoring of allograft rejection in kidney transplant recipients. Using extracellular vesicles as non‐invasive biomarkers for diagnosis of kidney allograft rejection could have tremendous benefits in improving patient outcomes and reduce the need for invasive procedures. [ABSTRACT FROM AUTHOR] |
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Copyright of Clinical Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
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