Bibliographic Details
| Title: |
Genetic barriers more than environmental associations explain Serratia marcescens population structure. |
| Authors: |
Sterzi, Lodovico, Nodari, Riccardo, Di Marco, Federico, Ferrando, Maria Laura, Saluzzo, Francesca, Spitaleri, Andrea, Allahverdi, Hamed, Papaleo, Stella, Panelli, Simona, Rimoldi, Sara Giordana, Batisti Biffignandi, Gherard, Corbella, Marta, Cavallero, Annalisa, Prati, Paola, Farina, Claudio, Cirillo, Daniela Maria, Zuccotti, Gianvincenzo, Bandi, Claudio, Comandatore, Francesco |
| Source: |
Communications Biology; 4/17/2024, Vol. 7 Issue 1, p1-12, 12p |
| Subject Terms: |
SERRATIA marcescens, REPRODUCTIVE isolation, GENOMICS, COMPARATIVE genomics, BACTERIAL population, GENE flow, METAGENOMICS |
| Abstract: |
Bacterial species often comprise well-separated lineages, likely emerged and maintained by genetic isolation and/or ecological divergence. How these two evolutionary actors interact in the shaping of bacterial population structure is currently not fully understood. In this study, we investigate the genetic and ecological drivers underlying the evolution of Serratia marcescens, an opportunistic pathogen with high genomic flexibility and able to colonise diverse environments. Comparative genomic analyses reveal a population structure composed of five deeply-demarcated genetic clusters with open pan-genome but limited inter-cluster gene flow, partially explained by Restriction-Modification (R-M) systems incompatibility. Furthermore, a large-scale research on hundred-thousands metagenomic datasets reveals only a partial habitat separation of the clusters. Globally, two clusters only show a separate gene composition coherent with ecological adaptations. These results suggest that genetic isolation has preceded ecological adaptations in the shaping of the species diversity, an evolutionary scenario coherent with the Evolutionary Extended Synthesis. A large comparative genomics study reveals that Serratia marcescens is composed of five main phylogenetic clusters, isolated by genetic barriers but not clearly separated by ecological specialisations. This results provides insights into the bacterial diversification process. [ABSTRACT FROM AUTHOR] |
|
Copyright of Communications Biology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
