Bibliographic Details
| Title: |
Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease. |
| Authors: |
Dittmar, David J., Pielmeier, Franziska, Strieder, Nicholas, Fischer, Alexander, Herbst, Michael, Stanewsky, Hanna, Wenzl, Niklas, Röseler, Eveline, Eder, Rüdiger, Gebhard, Claudia, Schwarzfischer-Pfeilschifter, Lucia, Albrecht, Christin, Herr, Wolfgang, Edinger, Matthias, Hoffmann, Petra, Rehli, Michael |
| Source: |
Nature Communications; 4/15/2024, Vol. 15 Issue 1, p1-16, 16p |
| Abstract: |
The adoptive transfer of regulatory T cells is a promising strategy to prevent graft-versus-host disease after allogeneic bone marrow transplantation. Here, we use a major histocompatibility complex-mismatched mouse model to follow the fate of in vitro expanded donor regulatory T cells upon migration to target organs. Employing comprehensive gene expression and repertoire profiling, we show that they retain their suppressive function and plasticity after transfer. Upon entering non-lymphoid tissues, donor regulatory T cells acquire organ-specific gene expression profiles resembling tissue-resident cells and activate hallmark suppressive and cytotoxic pathways, most evidently in the colon, when co-transplanted with graft-versus-host disease-inducing conventional T cells. Dominant T cell receptor clonotypes overlap between organs and across recipients and their relative abundance correlates with protection efficacy. Thus, this study reveals donor regulatory T cell selection and adaptation mechanisms in target organs and highlights protective features of Treg to guide the development of improved graft-versus-host disease prevention strategies. Graft-versus-Host disease is a major complication after allogeneic bone marrow transplantation and is ameliorated by adoptively transferred donor regulatory T cells. Here, the authors apply transcriptomic and TCR profiling to assess regulatory T cell organ-specific adaptation in murine bone marrow transplantation models. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
