Bibliographic Details
| Title: |
Plasma Concentrations of Oral Ondansetron in Hospitalized Dogs Exhibiting Clinical Signs of Nausea. |
| Authors: |
Zersen, Kristin M., Molli, Angela, Weisbeck, Brooke G., Fedotova, Samantha, Quimby, Jessica M., Gustafson, Daniel L., Shropshire, Sarah B. |
| Source: |
Veterinary Sciences; Mar2024, Vol. 11 Issue 3, p112, 9p |
| Subject Terms: |
ONDANSETRON, DOGS, SYMPTOMS, ORAL drug administration, NAUSEA, BLOOD plasma |
| Abstract: |
Simple Summary: Oral ondansetron is commonly prescribed to treat nausea and vomiting in dogs, but no studies have evaluated how well it is absorbed in clinical patients after oral administration. The objective of this study was to evaluate how well oral ondansetron is absorbed in a population of client-owned dogs with naturally occurring nausea. Twenty-four dogs were randomly assigned to receive one of the following doses of oral ondansetron, which are all within the currently recommended dose range: 0.5 mg/kg q8h, 0.5 mg/kg q12h, 1 mg/kg q8h, and 1 mg/kg q12h. Blood samples were collected for ondansetron measurement at various time points after administration of the first dose of ondansetron, and nausea scores were recorded. Ondansetron blood concentrations averaged over an 8 h time period were not significantly different between dose groups. The mean nausea scores at baseline were similar among all groups and decreased over time. Blood ondansetron concentrations were below the limit of detection in 44% (32/72) of all samples collected and were not detected at any timepoint in 25% (6/24) of the dogs. These results raise the concern that orally administered ondansetron at the current recommended dosages may not be absorbed into the bloodstream effectively. The purpose of this study was to evaluate plasma ondansetron (OND) concentrations in a population of dogs with naturally occurring nausea after oral OND administration. Twenty-four dogs were randomly assigned to receive one of the following doses of oral OND: 0.5 mg/kg q8h, 0.5 mg/kg q12h, 1 mg/kg q8h, or 1 mg/kg q12h. Blood samples for plasma OND measurements were collected at baseline and 2, 4, and 8 h after administration of the first dose of OND. OND concentrations averaged over an 8 h time period were not significantly different between dose groups (0.5 mg/kg group: median 8.5 ng/mL [range 1–96.8 ng/mL], 1 mg/kg group: median 7.4 ng/mL [range 1–278.7 ng/mL]). The mean maximum concentrations in the 0.5 mg/kg and 1 mg/kg groups were 35.8 ± 49.0 ng/mL and 63.3 ± 121.1 ng/mL, respectively. OND concentrations were below the lower limit of quantification (LLOQ) in 50% (18/36) of samples in the 0.5 mg/kg groups and 39% (14/36) of samples in the 1 mg/kg groups. Six dogs (6/24, 25%) did not have OND detected at any time. The mean nausea scores at baseline were similar amongst all groups and decreased over time. The bioavailability of oral OND appears to be poor. Despite low plasma OND concentrations, nausea scores improved over time. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
