Bibliographic Details
| Title: |
Efficacy and safety of fenofibrate in combination with phototherapy for the treatment of neonatal hyperbilirubinemia: a systematic review and meta-analyses. |
| Authors: |
Abdellatif, Mohammed, Abozaid, Ali Ahmed Fouad, Shah, Prakesh S., Dhouibi, Nacir, Nguyen-Khac, Thuan, Khleif, Rafeef, Luu, Mai Ngoc, Quyen, Dinh Kim, Mohareb, Anton, Vaghela, Gladson, Khan, Zeeshan Ali, Pham, Hoang Nhat, Makram, Abdelrahman M., Huy, Nguyen Tien |
| Source: |
Canadian Journal of Physiology & Pharmacology; 2024, Vol. 102 Issue 4, p242-253, 12p |
| Subject Terms: |
NEONATAL jaundice, FENOFIBRATE, PHOTOTHERAPY, BLOOD transfusion, RANDOM effects model, RANDOMIZED controlled trials, SAFETY, MEDITERRANEAN diet |
| Abstract: |
Phototherapy is the standard treatment for neonatal jaundice. We aimed to review the efficacy and safety of fenofibrate as an adjunct therapy. Twelve databases were searched and a systematic review and meta-analysis were conducted. Mean change (MC), mean difference (MD), and risk ratios (RR) with a 95% confidence interval (CI) were calculated using a random effects model. The GRADE approach was used to evaluate the evidence's certainty. Nine randomized trials were included. The MC of total serum bilirubin (mg/dL) was significant at 12, 24, 36, 48, and 72 h with respective MC (95% CI) values of −0.46 (−0.61, −0.310), −1.10 (−1.68, −0.52), −2.06 (−2.20, −1.91), −2.15 (−2.74, −1.56), and −1.13 (−1.71, −0.55). The FEN + PT group had a shorter duration of phototherapy (MD: −14.36 h; 95% CI: −23.67, −5.06) and a shorter hospital stay (MD: −1.40 days; 95% CI: −2.14, −0.66). There was no significant difference in the risk of complications (RR: 0.89; 95% CI: 0.54, 1.46) or the need for exchange transfusion (RR: 0.58; 95% CI: 0.12, 2.81). The certainty of the evidence was very low for all outcomes. In conclusion, fenofibrate might be a safe adjunct to neonatal phototherapy. Larger randomized controlled trials are needed for the confirmation of these results. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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