| Title: |
Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination. |
| Authors: |
de la Fuente, Alerie Guzman, Dittmer, Marie, Heesbeen, Elise J., de la Vega Gallardo, Nira, White, Jessica A., Young, Andrew, McColgan, Tiree, Dashwood, Amy, Mayne, Katie, Cabeza-Fernández, Sonia, Falconer, John, Rodriguez-Baena, Francisco Javier, McMurran, Christopher E., Inayatullah, Mohammed, Rawji, Khalil S., Franklin, Robin J. M., Dooley, James, Liston, Adrian, Ingram, Rebecca J., Tiwari, Vijay K. |
| Source: |
Nature Communications; 3/11/2024, Vol. 15 Issue 1, p1-19, 19p |
| Abstract: |
Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently emerged as critical players in tissue regeneration, including remyelination. However, the effect of ageing on Treg-mediated regenerative processes is poorly understood. Here, we show that expansion of aged Treg does not rescue age-associated remyelination impairment due to an intrinsically diminished capacity of aged Treg to promote oligodendrocyte differentiation and myelination in male and female mice. This decline in regenerative Treg functions can be rescued by a young environment. We identified Melanoma Cell Adhesion Molecule 1 (MCAM1) and Integrin alpha 2 (ITGA2) as candidates of Treg-mediated oligodendrocyte differentiation that decrease with age. Our findings demonstrate that ageing limits the neuroregenerative capacity of Treg, likely limiting their remyelinating therapeutic potential in aged patients, and describe two mechanisms implicated in Treg-driven remyelination that may be targetable to overcome this limitation.Factors limiting CNS remyelination with age are poorly understood. Here the authors show that aged Treg lose capacity to support CNS remyelination in mice, which can be restored in a young environment. [ABSTRACT FROM AUTHOR] |
|
Copyright of Nature Communications is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
