Bibliographic Details
| Title: |
Positivity Rate, Predictors, and Outcome of Paediatric Lassa Fever Disease (LFD) in a Lassa Fever Endemic State, South-East Nigeria. |
| Authors: |
Orji, Maria-Lauretta, Ajayi, Nnennaya Anthony, Onyire, Nnamdi Benson, Unigwe, Uche Sonny, Ojide, Chiedozie Kingsley |
| Source: |
Nigerian Medical Journal; May/Jun2021, Vol. 62 Issue 3, p133-138, 6p |
| Subject Terms: |
LASSA fever, DEATH rate, DIAGNOSTIC use of polymerase chain reaction, PEDIATRICS, CHILD death |
| Geographic Terms: |
NIGERIA |
| Abstract: |
Background: The pattern and case fatality rate of Paediatric Lassa fever disease (LFD) is not well documented even in Lassa fever endemic communities. Aim and Objective: This prospective observational study was aimed at determining the pattern and outcome of Paediatric LFD. Methodology: A total of 183 children that met the criteria for LFD suspects were subjected to the Lassa virus PCR test. The suspects that tested positive were recruited into the study and a structured questionnaire was used to collect information on socio-demographics. Results: Of the 183 LFD suspects that were tested, 24 of them were positive to Lassa virus PCR, giving a positivity rate of 13.1%. The mean duration of illness before hospital presentation was 8.54 ± 3.83 days. All the subjects had a history of fever. Abdominal pain and vomiting were the two highest presenting complaints after fever. Seven out of 24 children died during the study period, giving a case fatality rate (CFR) of 29.2%. Subjects who presented with convulsions and unconsciousness (OR = 10.00,95% CI= 1.2,81.81, p=0.020), bleeding (OR =40.00, 95% CI= 12.96, 539.67, p=0.020), poor urine output (OR =40.00, 95% CI= 12.96, 539.67, p=0.020) were more likely to die of LFD compared to their colleagues without such symptoms. Conclusion: The positivity rate and case fatality rate of LFD in children were high. Public enlightenment on the common features of Lassa fever disease and the need to seek health care early for children with febrile illness is advocated. [ABSTRACT FROM AUTHOR] |
|
Copyright of Nigerian Medical Journal is the property of Nigerian Medical Association, Department of Internal Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
