| Title: |
Objective Response and Progression-Free Survival Contribute to Prolong Overall Survival in Atezolizumab plus Bevacizumab Treatment for Unresectable Hepatocellular Carcinoma. |
| Authors: |
Tajiri, Kazuto, Tsukada, Kenichiro, Tokimitsu, Yoshiharu, Motofuji, Yuchi, Kawai, Kengo, Muraishi, Nozomu, Murayama, Aiko, Hayashi, Yuka, Shimizu, Yukihiro, Yasuda, Ichiro |
| Source: |
Oncology; 2024, Vol. 102 Issue 2, p131-140, 10p |
| Subject Terms: |
THERAPEUTIC use of monoclonal antibodies, THERAPEUTIC use of antineoplastic agents, DISEASE progression, RETROSPECTIVE studies, ACQUISITION of data, TREATMENT effectiveness, CANCER patients, SURVIVAL analysis (Biometry), DESCRIPTIVE statistics, MEDICAL records, BEVACIZUMAB, PROGRESSION-free survival, HEPATOCELLULAR carcinoma, OVERALL survival |
| Abstract: |
Introduction: Atezolizumab plus bevacizumab (Atez/Bev) is a standard treatment for unresectable hepatocellular carcinoma (HCC) due to its good antitumor and survival prolongation effects. Post-progression survival (PPS) has been reported to be a great contributor in the treatment with tyrosine kinase inhibitors for unresectable HCC. This study aimed to clarify the significance of progression-free survival (PFS) or PPS of Atez/Bev treatment for HCC. Methods: We analyzed the correlations of PFS and PPS with overall survival (OS) in studies of HCC patients treated with Atez/Bev and evaluated the contribution to OS in Atez/Bev treatment with patients at our institutions as clinical practice. Results: Analysis of 18 studies involving 3,752 patients treated with Atez/Bev found that PPS had a stronger correlation with OS (R2 = 0.872, p < 0.001) than did PFS (R2 = 0.605, p = 0.001). Analysis of 80 patients with unresectable HCC treated with Atez/Bev found that presence of antitumor responses during Atez/Bev was the most significant contributor to OS, and post-progression treatment after Atez/Bev also significantly contribute to OS. Conclusion: The presence of antitumor response with tumor shrinkage during Atez/Bev treatment contributes to good OS through its durable response. Atez/Bev treatment could be considered as first-line treatment for unresectable HCC. However, there is a need for optimal biomarkers for good antitumor response. [ABSTRACT FROM AUTHOR] |
|
Copyright of Oncology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
