Bibliographic Details
| Title: |
A systematic review of antimicrobial treatment regimens and their outcomes in necrotising otitis externa. |
| Authors: |
Lodhi, Sirat, Timms, Sara, Stapleton, Emma |
| Source: |
Journal of Laryngology & Otology; Feb2024, Vol. 138 Issue 2, p120-129, 10p |
| Subject Terms: |
ONLINE information services, CINAHL database, MEDICAL databases, OTITIS externa, MEDICAL information storage & retrieval systems, SYSTEMATIC reviews, ANTI-infective agents, EVIDENCE-based medicine, TREATMENT effectiveness, DESCRIPTIVE statistics, MEDLINE, EVALUATION |
| Abstract: |
Background: Necrotising otitis externa is a serious infection with minimal evidence underpinning its management. This review aims to synthesise published evidence of antimicrobial therapies and their outcomes in necrotising otitis externa. Methods: The review was PROSPERO registered (CRD42022353244) and conducted according to Preferred Reporting Items for Systematic Review and Meta-Analyses ('PRISMA') guidelines. A robust search strategy filtered 28 manuscripts into the final review. Antimicrobial therapy and clinical outcome data were extracted and analysed. Results: Published studies are heterogeneous, with high risk of bias and low certainty. Reporting of outcomes is poor and extremely variable. First-line therapy is most commonly in-patient (95 per cent) empiric fluoroquinolone (68 per cent) delivered intravenously (82 per cent). The lack of granular data and poor outcome reporting mean it is impossible to correlate treatment strategies with clinical outcomes. Conclusion: Robust, consistent outcome reporting with reference to treatments administered is mandatory, to inform clinical management and optimise future research. Optimal antimicrobial choices and treatment strategies require clarification through prospective clinical trials. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Laryngology & Otology is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
