Bibliographic Details
| Title: |
Detection of diabetic neovascularisation using single-capture 65°-widefield optical coherence tomography angiography. |
| Authors: |
Heiko Stino, Niederleithner, Michael, Iby, Johannes, Sedova, Aleksandra, Schleg, Thomas, Steiner, Irene, Sacu, Stefan, Drexler, Wolfgang, Schmol, Tilman, Leitgeb, Rainer, Schmidt-Erfurth, Ursula Margarethe, Pollreisz, Andreas |
| Source: |
British Journal of Ophthalmology; Jan2024, Vol. 108 Issue 1, p91-97, 7p |
| Abstract: |
Aim To assess the detection rate of retinal neovascularisation (NV) in eyes with proliferative diabetic retinopathy (PDR) using widefield optical coherence tomography angiography (WF-OCTA) in comparison to ultrawidefield fluorescein angiography (UWF-FA). Methods Single-capture 65°-WF-OCTA-imaging was performed in patients with NV at the disc or elsewhere (NVE) detected on UWF-FA using a modified PlexElite system and B-scans were examined for blood flow signals breaching the internal limiting membrane. Sensitivity of WF-OCTA and UWF colour fundus (UWF-CF) photography for correct diagnosis of PDR was determined and interdevice agreement (Fleiss' κ) between WF-OCTA and UWF-FA for detection of NV in the total gradable area and each retinal quadrant was evaluated. Results Fifty-nine eyes of 41 patients with PDR detected on UWF-FA were included. Sensitivity of detecting PDR on WF-OCTA scans was 0.95 in contrast to 0.78 on UWF-CF images. Agreement in detecting NVE between WF-OCTA and UWF-FA was high in the superotemporal (κ=0.98) and inferotemporal (κ=0.94) and weak in the superonasal (κ=0.24) and inferonasal quadrants (κ=0.42). On UWF-FA, 63% of NVEs (n=153) were located in the temporal quadrants with 93% (n=142) of them being detected on WF-OCTA scans. Conclusion The high reliability of non-invasive WF-OCTA imaging in detecting PDR can improve clinical examination with the potential to replace FA as a single diagnostic tool. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
