Bibliographic Details
| Title: |
Serum microRNA Profiles and Pathways in Hepatitis B-Associated Hepatocellular Carcinoma: A South African Study. |
| Authors: |
Sartorius, Kurt, Sartorius, Benn, Winkler, Cheryl, Chuturgoon, Anil, Shen, Tsai-Wei, Zhao, Yongmei, An, Ping |
| Source: |
International Journal of Molecular Sciences; Jan2024, Vol. 25 Issue 2, p975, 26p |
| Subject Terms: |
GENE expression, HEPATOCELLULAR carcinoma, MICRORNA, HEPATITIS |
| Geographic Terms: |
SUB-Saharan Africa |
| Abstract: |
The incidence and mortality of hepatocellular carcinoma (HCC) in Sub-Saharan Africa is projected to increase sharply by 2040 against a backdrop of limited diagnostic and therapeutic options. Two large South African-based case control studies have developed a serum-based miRNome for Hepatitis B-associated hepatocellular carcinoma (HBV-HCC), as well as identifying their gene targets and pathways. Using a combination of RNA sequencing, differential analysis and filters including a unique molecular index count (UMI) ≥ 10 and log fold change (LFC) range > 2: <−0.5 (p < 0.05), 91 dysregulated miRNAs were characterized including 30 that were upregulated and 61 were downregulated. KEGG analysis, a literature review and other bioinformatic tools identified the targeted genes and HBV-HCC pathways of the top 10 most dysregulated miRNAs. The results, which are based on differentiating miRNA expression of cases versus controls, also develop a serum-based miRNA diagnostic panel that indicates 95.9% sensitivity, 91.0% specificity and a Youden Index of 0.869. In conclusion, the results develop a comprehensive African HBV-HCC miRNome that potentially can contribute to RNA-based diagnostic and therapeutic options. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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