| Title: |
Identifying novel inhibitors targeting Exportin-1 for the potential treatment of COVID-19. |
| Authors: |
Sharma, Tanuj, Mondal, Tanmoy, Khan, Sajid, Churqui, Marianela Patzi, Nyström, Kristina, Thombare, Ketan, Baig, Mohammad Hassan, Dong, Jae-June |
| Source: |
Archives of Microbiology; Feb2024, Vol. 206 Issue 2, p1-11, 11p |
| Abstract: |
The nuclear export protein 1 (XPO1) mediates the nucleocytoplasmic transport of proteins and ribonucleic acids (RNAs) and plays a prominent role in maintaining cellular homeostasis. XPO1 has emerged as a promising therapeutic approach to interfere with the lifecycle of many viruses. In our earlier study, we proved the inhibition of XPO1 as a therapeutic strategy for managing SARS-COV-2 and its variants. In this study, we have utilized pharmacophore-assisted computational methods to identify prominent XPO1 inhibitors. After several layers of screening, a few molecules were shortlisted for further experimental validation on the in vitro SARS-CoV-2 cell infection model. It was observed that these compounds reduced spike positivity, suggesting inhibition of SARS-COV-2 infection. The outcome of this study could be considered further for developing novel antiviral therapeutic strategies against SARS-CoV-2. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
