Bibliographic Details
| Title: |
Mucosal response of inactivated and recombinant COVID‐19 vaccines in Congolese individuals. |
| Authors: |
Mouzinga, Freisnel H., Heinzel, Constanze, Lissom, Abel, Kreidenweiss, Andrea, Batchi‐Bouyou, Armel L., Mbama Ntabi, Jacques D., Djontu, Jean C., Ngumbi, Etienne, Kremsner, Peter G., Fendel, Rolf, Ntoumi, Francine |
| Source: |
Immunity, Inflammation & Disease; Dec2023, Vol. 11 Issue 12, p1-11, 11p |
| Subject Terms: |
COVID-19 vaccines, BACTERIAL vaccines, COVID-19, BCG vaccines, ANTIBODY formation, ENZYME-linked immunosorbent assay, VACCINATION status |
| Abstract: |
Background: The efficacy of immunization against an airborne pathogen depends in part on its ability to induce antibodies at the major entry site of the virus, the mucosa. Recent studies have revealed that mucosal immunity is poorly activated after vaccination with messenger RNA vaccines, thus failing in blocking virus acquisition upon its site of initial exposure. Little information is available about the induction of mucosal immunity by inactivated and recombinant coronavirus disease 2019 (COVID‐19) vaccines. This study aims to investigate this topic. Methods: Saliva and plasma samples from 440 healthy Congolese were collected including (1) fully vaccinated 2 month postvaccination with either an inactivated or a recombinant COVID‐19 vaccine and (2) nonvaccinated control group. Total anti‐severe acute respiratory syndrome coronavirus 2 receptor‐binding domain IgG and IgA antibodies were assessed using in‐house enzyme‐linked immunosorbent assays for both specimens. Findings: Altogether, the positivity of IgG was significantly higher in plasma than in saliva samples both in vaccinated and nonvaccinated control groups. Inversely, IgA positivity was slightly higher in saliva than in plasma of vaccinated group. The overall IgG and IgA levels were respectively over 103 and 14 times lower in saliva than in plasma samples. We found a strong positive correlation between IgG in saliva and plasma also between IgA in both specimens (r =.70 for IgG and r =.52 for IgA). Interestingly, contrary to IgG, the level of salivary IgA was not different between seropositive control group and seropositive vaccinated group. No significant difference was observed between recombinant and inactivated COVID‐19 vaccines in total IgG and IgA antibody concentration release 2 months postvaccination both in plasma and saliva. Conclusion: Inactivated and recombinant COVID‐19 vaccines in use in the Republic of Congo poorly activated mucosal IgA‐mediated antibody response 2 months postvaccination. [ABSTRACT FROM AUTHOR] |
|
Copyright of Immunity, Inflammation & Disease is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
|
Full text is not displayed to guests. |
Login for full access.
|
