Causal Effect of Selenium Levels on Osteoporosis: A Mendelian Randomization Study.
| Title: | Causal Effect of Selenium Levels on Osteoporosis: A Mendelian Randomization Study. |
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| Authors: | Li, Jinjie, Li, Hong, Ullah, Amin, Yao, Shuyuan, Lyu, Quanjun, Kou, Guangning |
| Source: | Nutrients; Dec2023, Vol. 15 Issue 24, p5065, 14p |
| Abstract: | Prior research has demonstrated equivocal associations between selenium (Se) concentrations and osteoporosis (OP), yielding inconclusive findings. The purpose of the current study was to examine the potential correlation between Se levels and the risk of OP by using the Mendelian randomization (MR) study design. The genetic variants related to Se levels were obtained from a meta-analysis of a Genome-Wide Association Study (GWAS) conducted on toenail Se levels (n = 4162) and blood Se levels (n = 5477). The data summary for OP and bone mineral density (BMD) was obtained by utilizing the GWAS database. To examine the association between Se levels and BMD and OP, we employed three statistical methods: inverse variance weighted, weighted median, and MR-Egger. The reliability of the analysis was verified by sensitivity testing. All three methods of MR analysis revealed that Se levels had no effect on OP risk. In addition, the sensitivity analysis revealed no heterogeneity or pleiotropy, and the significance of the overall effect remained unaffected by single-nucleotide polymorphisms (SNPs), as determined by the leave-one-out analysis, indicating that our findings are relatively reliable. The results of our study indicate that there is no causal association between Se levels and the risk of OP. However, additional investigation is necessary to ascertain whether there is a potential association between these variables. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Causal Effect of Selenium Levels on Osteoporosis: A Mendelian Randomization Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Li%2C+Jinjie%22">Li, Jinjie</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Hong%22">Li, Hong</searchLink><br /><searchLink fieldCode="AR" term="%22Ullah%2C+Amin%22">Ullah, Amin</searchLink><br /><searchLink fieldCode="AR" term="%22Yao%2C+Shuyuan%22">Yao, Shuyuan</searchLink><br /><searchLink fieldCode="AR" term="%22Lyu%2C+Quanjun%22">Lyu, Quanjun</searchLink><br /><searchLink fieldCode="AR" term="%22Kou%2C+Guangning%22">Kou, Guangning</searchLink> – Name: TitleSource Label: Source Group: Src Data: Nutrients; Dec2023, Vol. 15 Issue 24, p5065, 14p – Name: Abstract Label: Abstract Group: Ab Data: Prior research has demonstrated equivocal associations between selenium (Se) concentrations and osteoporosis (OP), yielding inconclusive findings. The purpose of the current study was to examine the potential correlation between Se levels and the risk of OP by using the Mendelian randomization (MR) study design. The genetic variants related to Se levels were obtained from a meta-analysis of a Genome-Wide Association Study (GWAS) conducted on toenail Se levels (n = 4162) and blood Se levels (n = 5477). The data summary for OP and bone mineral density (BMD) was obtained by utilizing the GWAS database. To examine the association between Se levels and BMD and OP, we employed three statistical methods: inverse variance weighted, weighted median, and MR-Egger. The reliability of the analysis was verified by sensitivity testing. All three methods of MR analysis revealed that Se levels had no effect on OP risk. In addition, the sensitivity analysis revealed no heterogeneity or pleiotropy, and the significance of the overall effect remained unaffected by single-nucleotide polymorphisms (SNPs), as determined by the leave-one-out analysis, indicating that our findings are relatively reliable. The results of our study indicate that there is no causal association between Se levels and the risk of OP. However, additional investigation is necessary to ascertain whether there is a potential association between these variables. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Nutrients is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nu15245065 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 5065 Titles: – TitleFull: Causal Effect of Selenium Levels on Osteoporosis: A Mendelian Randomization Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li, Jinjie – PersonEntity: Name: NameFull: Li, Hong – PersonEntity: Name: NameFull: Ullah, Amin – PersonEntity: Name: NameFull: Yao, Shuyuan – PersonEntity: Name: NameFull: Lyu, Quanjun – PersonEntity: Name: NameFull: Kou, Guangning IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 12 Text: Dec2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 20726643 Numbering: – Type: volume Value: 15 – Type: issue Value: 24 Titles: – TitleFull: Nutrients Type: main |
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