Bibliographic Details
| Title: |
Silver Nanoparticles and Graphene Oxide Complex as an Anti-Inflammatory Biocompatible Liquid Nano-Dressing for Skin Infected with Staphylococcus aureus. |
| Authors: |
Zielińska-Górska, Marlena, Sosnowska-Ławnicka, Malwina, Jaworski, Sławomir, Lange, Agata, Daniluk, Karolina, Nasiłowska, Barbara, Bartosewicz, Bartosz, Chwalibog, André, Sawosz, Ewa |
| Source: |
Journal of Inflammation Research; Nov2023, Vol. 16, p5477-5493, 17p |
| Subject Terms: |
SILVER nanoparticles, GRAPHENE oxide, LIFE sciences, STAPHYLOCOCCUS aureus, ARTIFICIAL skin |
| Geographic Terms: |
POLAND, SLOVAKIA |
| Abstract: |
Background: Bacterial skin infections, including Staphylococcus aureus, are a powerful and still not fully resolved problem. The aim of this research was to determine the possibility of using a complex of graphene oxide (GO) encrusted with silver nanoparticles as an effective antibacterial agent against S. aureus and to assess its pro-inflammatory properties.Methods: The tests were carried out in vitro on EpiDerm™ Skin, an artificial skin model (MatTek in vitro Life Science Laboratories, Slovak Republic), and the fibroblast cell line (HFF-2 from ATCC, USA). Both models were infected with S. aureus bacteria (ATCC 25923) and then treated with antibiotics or our experimental factors: silver nanoparticles (AgNPs, Nano-koloid, Poland), graphene oxide (GO, NanoPoz, Poland), and complex AgNP-GO (hydrocolloid created by self-assembly).Results: The antibacterial effectiveness of the AgNP-GO complex was equivalent to that of the antibiotic. In addition, an increase in the level of pro-inflammatory cytokines was observed under the influence of antibiotic administration, in contrast to the effect of AgNP-GO, which showed very limited pro-inflammatory activity.Conclusion: Hydrocolloid of the AgNP-GO complex, administered in the form of a liquid dressing, may act as an antibacterial agent and also reduce inflammation induced by S. aureus infection. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Inflammation Research is the property of Dove Medical Press Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
