| Title: |
Exploring the Changing Diagnostic Criteria of Gorlin-Goltz Syndrome: A Case Report. |
| Authors: |
Shetty, Sahith Kumar, Doddawad, Vidya G., Sundar, Shyam, S., Shivananda |
| Source: |
Oncology (08909091); Nov2023, Vol. 37 Issue 11, p449-454, 6p |
| Abstract: |
Gorlin-Goltz syndrome, also known as Gorlin syndrome, basal cell nevus syndrome, and nevoid basal cell carcinoma syndrome, is an autosomal dominant genetic disorder. Its hallmark is an early onset of basal cell carcinoma. Additionally, the syndrome is characterized by a spectrum of distinct clinical attributes encompassing oral, skeletal, ophthalmic, neurological, and developmental aberrations. This condition arises due to anomalies in the Hedgehog signaling pathway, leading to constant pathway activity and uncontrolled growth of tumor cells. Early identification of the disorder through available diagnostic methods and clinical and radiological findings is crucial for accurate diagnosis, which subsequently leads to the formulation of an effective treatment regimen. The purpose of this case report is to discuss the role of a dentist in early detection based on various author-prescribed criteria and the need for a multidisciplinary approach to the treatment of patients with this syndrome. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
