Bibliographic Details
| Title: |
Editorial for "Alterations in Resting‐State MR Functional Connectivity of the Central Autonomic Network in Multiple System Atrophy and Relationship With Disease Severity". |
| Authors: |
Ye, Zezhong, Gary, Sam E. |
| Source: |
Journal of Magnetic Resonance Imaging; Nov2023, Vol. 58 Issue 5, p1488-1489, 2p |
| Subject Terms: |
MULTIPLE system atrophy, FUNCTIONAL connectivity, SINGLE-photon emission computed tomography |
| Abstract: |
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder, characterized by -synuclein inclusions and neuronal loss and gliosis in the striatonigral, olivopontocerebellar, and spinal nuclei structures of the central autonomic nervous (CAN) system.[[1]] The annual incidence of MSA is estimated to be about 0.6 per 100,000 per year, with a higher incidence of 3 per 100,000 per year observed in individuals above the age of 50.[1] Although MSA is clinically classified into two subtypes, namely MSA-C, involving predominant cerebellar ataxia, and MSA-P, involving predominant parkinsonism, autonomic failure is a common feature of both subtypes, and many patients develop symptoms of both MSA-C and MSA-P as the disease progresses, indicating the heterogeneity of structures affected in the brain.[3] Medical imaging modalities including routine magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), voxel-based morphometry, and transcranial sonography have been employed to identify brainstem or basal-ganglia abnormalities present in early diagnosis of MSA.[[1]] Recently, functional imaging techniques such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) were also advocated in the early diagnosis of MSA.[[1]] However, these methods lack the sensitivity and functional relevance needed to determine the network disruption and subsequent autonomic dysfunction that defines MSA. Yet, the degree of structural atrophy lacks consistent correlation with the severity of clinical disability in MSA, indicating the existence of other functional deterioration factors that contribute to the variable disease severity. [Extracted from the article] |
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| Database: |
Complementary Index |
