Bibliographic Details
| Title: |
Cell and cytokine analyses from bronchoalveolar lavage in non-critical COVID-19 pneumonia. |
| Authors: |
Rolland-Debord, Camille, Piéroni, Laurence, Bejar, Farah, Milon, Audrey, Choinier, Pascaline, Blin, Emmanuelle, Bravais, Juliette, Halitim, Pierre, Letellier, Alice, Camuset, Juliette, Parrot, Antoine, Fajac, Anne, Cadranel, Jacques |
| Source: |
Internal & Emergency Medicine; Sep2023, Vol. 18 Issue 6, p1723-1732, 10p |
| Abstract: |
Cell and cytokine analyses from bronchoalveolar lavage (BAL) in non-critically ill patients with COVID-19 pneumonia are poorly described. This study focused on patients hospitalized in the non-intensive care unit for either suspected COVID-19 pneumonia or persistent respiratory symptoms following proven COVID-19 pneumonia. Overall, 54 patients who underwent BAL between April 2020 and February 2021 for suspected or follow-up of proven COVID-19 pneumonia were included. Based on SARS-CoV-2 polymerase chain reaction test results and clinical follow-up, three pulmonary disease groups were defined: non-COVID-19 (n = 20), acute COVID-19 (n = 13), and post-COVID-19 (n = 24) pneumonia patients. Cytological and cytokine analyses were performed on BAL fluid (IL-1β, IL-6, IL-8, IL-10, TNF-α, IFN-γ, HGF, and TGF-β), with investigators blinded to the patient groups. Lymphocytic alveolitis with plasmocytes was observed in acute COVID-19 pneumonia, returning to normal post-COVID-19. The highest cytokine levels were observed in COVID-19 patients, with significantly increased IFN-γ, IL-10, and HGF levels compared to non-COVID-19 patients, while significantly decreased IL-6, IL-8, IL-10, IFN-γ, TNF-α, and HGF levels were noted in post-COVID-19 patients. In COVID-19 patients, correlations between IL-10, TNF-α and IFN-γ concentrations were found. Lymphocytic alveolitis with plasmacytosis was found in non-critical COVID-19 pneumonia This alveolitis is associated with the presence of IL-6, IL-8, IL-10, TNF-α, IFN-γ and HGF. Alveolitis and cytokines levels decreased in post-COVID-19 pneumonia. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
