| Title: |
The Diagnostic and Prognostic Roles Played by Homocysteine and Other Aminothiols in Patients with Chronic Kidney Disease. |
| Authors: |
Kruglova, Maria Petrovna, Ivanov, Alexander Vladimirovich, Fedoseev, Anatolij Nikolaevich, Virus, Edward Danielevich, Stupin, Victor Aleksandrovich, Parfenov, Vladimir Anatolyevich, Titova, Svetlana Andreevna, Lazareva, Polina Igorevna, Kubatiev, Aslan Amirkhanovich, Silina, Ekaterina Vladimirovna |
| Source: |
Journal of Clinical Medicine; Sep2023, Vol. 12 Issue 17, p5653, 13p |
| Subject Terms: |
CHRONIC kidney failure, CHRONICALLY ill, HOMOCYSTEINE, CAPILLARY electrophoresis, BLOOD plasma |
| Abstract: |
We examined standard clinical and laboratory biochemical parameters, as well as the levels of aminothiols in the blood and urine (homocysteine (Hcy), cysteine (Cys), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH)) via capillary electrophoresis in patients with CKD at stages II–V. Patient outcomes were assessed after five years. To complete forecasting, correlation and ROC analysis were performed. It was found that the levels of Cys and Hcy in blood plasma were earlier markers of CKD starting from stage II, while the levels of SAM and SAM/SAH in urine made it possible to differentiate between CKD at stages II and III. Blood plasma Hcy and urinary SAM and SAM/SAH correlated with mortality, but plasma Hcy concentrations were more significant. Thus, plasma Hcy, urine SAM, and SAM/SAH can be considered to be potential diagnostic and prognostic markers in patients with CKD. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
