Bibliographic Details
| Title: |
Direct Introduction of −OCD3 into the Hantzsch Pyrrole Synthesis via Multicomponent Cascade Cyclization: Synthesis of Fully Substituted Pyrrole Derivatives. |
| Authors: |
Wang, Li‐Sheng, Zhou, You, Lei, Shuang‐Gui, Tang, Bo‐Cheng, Yu, Zhi‐Cheng, Tang, Yong‐Xing, Wu, Yan‐Dong, Wu, An‐Xin |
| Source: |
Advanced Synthesis & Catalysis; 9/5/2023, Vol. 365 Issue 17, p2888-2893, 6p |
| Subject Terms: |
PYRROLES, PYRROLE derivatives, RING formation (Chemistry), METHYL ketones, ANILINE |
| Abstract: |
A I2‐DMSO mediated approach to introduce −OCD3 into pyrroles in situ via multicomponent cascade cyclization reaction using methyl ketones, aniline, ethyl benzoylacetate and CD3OD as readily available substrates is reported. This process realizes introduction of −OCD3 into the Hantzsch pyrrole synthesis and synthesis of deuterated alkoxy‐substituted pyrroles with formation of one C−C bond, one C−O bond and two C−N bonds in one pot. Notably, this conversion has good substrate compatibility (62 examples) and eliminates of the need for anhydrous and anaerobic operation. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
