| Title: |
Effects of melatonin on plasma levels of TNF-α, IL-1 and IL-6 in mice after lipopolysaccharide administration. |
| Authors: |
Bitzer-Quintero, Oscar K, Ortiz, Genaro G, Ruiz-Rizo, Leonel, Torres-Mendoza, Blanca M, Vázquez-Valls, Eduardo, Rodríguez-Pérez, Miguel |
| Source: |
Biological Rhythm Research; Feb-Apr2005, Vol. 36 Issue 1/2, p159-168, 10p |
| Subject Terms: |
MELATONIN, HORMONES, BLOOD plasma, IMMUNE system, NEUROENDOCRINE cells, ENDOTOXINS |
| Abstract: |
Bidirectional dependence exists between the immune and neuroendocrine systems, with common chemical messengers, such as melatonin (MLT), having immunoregulatory functions in some mechanisms of endotoxic shock. We used 10?–?12-week-old female Balb/c mice, with an average weight of 22?–?24?g, maintained under a 12?h light?–?dark cycle. The LD100 of lipopolysaccharide (LPS) was determined to be 10?mg/kg (ip.) from a dose?–?response curve. Pretreatment with MLT (10?mg/kg ip.) increased survival by 60%, decreased plasma TNF-a? and increased IL-1. No significant changes were observed in levels of plasma IL-6. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
