| Title: |
Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products. |
| Authors: |
Calderon, Jhon Jairo, Prieto, Karol, Lasso, Paola, Fiorentino, Susana, Barreto, Alfonso |
| Source: |
Archivum Immunologiae & Therapiae Experimentalis; 7/6/2023, Vol. 71 Issue 1, p1-16, 16p |
| Abstract: |
During carcinogenesis, the microenvironment plays a fundamental role in tumor progression and resistance. This tumor microenvironment (TME) is characterized by being highly immunosuppressive in most cases, which makes it an important target for the development of new therapies. One of the most important groups of cells that orchestrate immunosuppression in TME is myeloid-derived suppressor cells (MDSCs), which have multiple mechanisms to suppress the immune response mediated by T lymphocytes and thus protect the tumor. In this review, we will discuss the importance of modulating MDSCs as a therapeutic target and how the use of natural products, due to their multiple mechanisms of action, can be a key alternative for modulating these cells and thus improve response to therapy in cancer patients. [ABSTRACT FROM AUTHOR] |
|
Copyright of Archivum Immunologiae & Therapiae Experimentalis is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
