Early activation and recruitment of invariant natural killer T cells during liver ischemiareperfusion: the major role of the alarmin interleukin-33.
| Title: | Early activation and recruitment of invariant natural killer T cells during liver ischemiareperfusion: the major role of the alarmin interleukin-33. |
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| Authors: | Robin, Aurélie, Mackowiak, Claire, Bost, Romain, Dujardin, Fanny, Barbarin, Alice, Thierry, Antoine, Hauet, Thierry, Pellerin, Luc, Gombert, Jean-Marc, Salamé, Ephrem, Herbelin, André, Barbier, Louise |
| Source: | Frontiers in Immunology; 2023, p1-12, 12p |
| Subject Terms: | CYTOTOXIC T cells, KILLER cells, LIVER cells, INTERLEUKIN-33, T cells, GRAFT versus host reaction, PATIENT Activation Measure, MYOCARDIAL reperfusion |
| Abstract: | Over the past thirty years, the complexity of the ab-T cell compartment has been enriched by the identification of innate-like T cells (ITCs), which are composed mainly of invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells. Based on animal studies using ischemia-reperfusion (IR) models, a key role has been attributed to iNKT cells in close connection with the alarmin/cytokine interleukin (IL)-33, as early sensors of cell-stress in the initiation of acute sterile inflammation. Here we have investigated whether the new concept of a biological axis of circulating iNKT cells and IL-33 applies to humans, and may be extended to other ITC subsets, namely MAIT and gd-T cells, in the acute sterile inflammation sequence occurring during liver transplant (LT). From a prospective biological collection of recipients, we reported that LT was accompanied by an early and preferential activation of iNKT cells, as attested by almost 40% of cells having acquired the expression of CD69 at the end of LT (i.e. 1-3 hours after portal reperfusion), as opposed to only 3-4% of conventional T cells. Early activation of iNKT cells was positively correlated with the systemic release of the alarmin IL-33 at graft reperfusion. Moreover, in a mouse model of hepatic IR, iNKT cells were activated in the periphery (spleen), and recruited in the liver in WT mice, as early as the first hour after reperfusion, whereas this phenomenon was virtually missing in IL-33-deficient mice. Although to a lesser degree than iNKT cells, MAIT and gd-T cells also seemed targeted during LT, as attested by 30% and 10% of them acquiring CD69 expression, respectively. Like iNKT cells, and in clear contrast to gd-T cells, activation of MAIT cells during LT was closely associated with both release of IL-33 immediately after graft reperfusion and severity of liver dysfunction occurring during the first three post-operative days. All in all, this study identifies iNKT and MAIT cells in connection with IL-33 as new key cellular factors and mechanisms of acute sterile inflammation in humans. Further investigations are required to confirm the implication of MAIT and iNKT cell subsets, and to precisely assess their functions, in the clinical course of sterile inflammation accompanying LT. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Early activation and recruitment of invariant natural killer T cells during liver ischemiareperfusion: the major role of the alarmin interleukin-33. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Robin%2C+Aurélie%22">Robin, Aurélie</searchLink><br /><searchLink fieldCode="AR" term="%22Mackowiak%2C+Claire%22">Mackowiak, Claire</searchLink><br /><searchLink fieldCode="AR" term="%22Bost%2C+Romain%22">Bost, Romain</searchLink><br /><searchLink fieldCode="AR" term="%22Dujardin%2C+Fanny%22">Dujardin, Fanny</searchLink><br /><searchLink fieldCode="AR" term="%22Barbarin%2C+Alice%22">Barbarin, Alice</searchLink><br /><searchLink fieldCode="AR" term="%22Thierry%2C+Antoine%22">Thierry, Antoine</searchLink><br /><searchLink fieldCode="AR" term="%22Hauet%2C+Thierry%22">Hauet, Thierry</searchLink><br /><searchLink fieldCode="AR" term="%22Pellerin%2C+Luc%22">Pellerin, Luc</searchLink><br /><searchLink fieldCode="AR" term="%22Gombert%2C+Jean-Marc%22">Gombert, Jean-Marc</searchLink><br /><searchLink fieldCode="AR" term="%22Salamé%2C+Ephrem%22">Salamé, Ephrem</searchLink><br /><searchLink fieldCode="AR" term="%22Herbelin%2C+André%22">Herbelin, André</searchLink><br /><searchLink fieldCode="AR" term="%22Barbier%2C+Louise%22">Barbier, Louise</searchLink> – Name: TitleSource Label: Source Group: Src Data: Frontiers in Immunology; 2023, p1-12, 12p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22CYTOTOXIC+T+cells%22">CYTOTOXIC T cells</searchLink><br /><searchLink fieldCode="DE" term="%22KILLER+cells%22">KILLER cells</searchLink><br /><searchLink fieldCode="DE" term="%22LIVER+cells%22">LIVER cells</searchLink><br /><searchLink fieldCode="DE" term="%22INTERLEUKIN-33%22">INTERLEUKIN-33</searchLink><br /><searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink><br /><searchLink fieldCode="DE" term="%22GRAFT+versus+host+reaction%22">GRAFT versus host reaction</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENT+Activation+Measure%22">PATIENT Activation Measure</searchLink><br /><searchLink fieldCode="DE" term="%22MYOCARDIAL+reperfusion%22">MYOCARDIAL reperfusion</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Over the past thirty years, the complexity of the ab-T cell compartment has been enriched by the identification of innate-like T cells (ITCs), which are composed mainly of invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells. Based on animal studies using ischemia-reperfusion (IR) models, a key role has been attributed to iNKT cells in close connection with the alarmin/cytokine interleukin (IL)-33, as early sensors of cell-stress in the initiation of acute sterile inflammation. Here we have investigated whether the new concept of a biological axis of circulating iNKT cells and IL-33 applies to humans, and may be extended to other ITC subsets, namely MAIT and gd-T cells, in the acute sterile inflammation sequence occurring during liver transplant (LT). From a prospective biological collection of recipients, we reported that LT was accompanied by an early and preferential activation of iNKT cells, as attested by almost 40% of cells having acquired the expression of CD69 at the end of LT (i.e. 1-3 hours after portal reperfusion), as opposed to only 3-4% of conventional T cells. Early activation of iNKT cells was positively correlated with the systemic release of the alarmin IL-33 at graft reperfusion. Moreover, in a mouse model of hepatic IR, iNKT cells were activated in the periphery (spleen), and recruited in the liver in WT mice, as early as the first hour after reperfusion, whereas this phenomenon was virtually missing in IL-33-deficient mice. Although to a lesser degree than iNKT cells, MAIT and gd-T cells also seemed targeted during LT, as attested by 30% and 10% of them acquiring CD69 expression, respectively. Like iNKT cells, and in clear contrast to gd-T cells, activation of MAIT cells during LT was closely associated with both release of IL-33 immediately after graft reperfusion and severity of liver dysfunction occurring during the first three post-operative days. All in all, this study identifies iNKT and MAIT cells in connection with IL-33 as new key cellular factors and mechanisms of acute sterile inflammation in humans. Further investigations are required to confirm the implication of MAIT and iNKT cell subsets, and to precisely assess their functions, in the clinical course of sterile inflammation accompanying LT. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Frontiers in Immunology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3389/fimmu.2023.1099529 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1 Subjects: – SubjectFull: CYTOTOXIC T cells Type: general – SubjectFull: KILLER cells Type: general – SubjectFull: LIVER cells Type: general – SubjectFull: INTERLEUKIN-33 Type: general – SubjectFull: T cells Type: general – SubjectFull: GRAFT versus host reaction Type: general – SubjectFull: PATIENT Activation Measure Type: general – SubjectFull: MYOCARDIAL reperfusion Type: general Titles: – TitleFull: Early activation and recruitment of invariant natural killer T cells during liver ischemiareperfusion: the major role of the alarmin interleukin-33. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Robin, Aurélie – PersonEntity: Name: NameFull: Mackowiak, Claire – PersonEntity: Name: NameFull: Bost, Romain – PersonEntity: Name: NameFull: Dujardin, Fanny – PersonEntity: Name: NameFull: Barbarin, Alice – PersonEntity: Name: NameFull: Thierry, Antoine – PersonEntity: Name: NameFull: Hauet, Thierry – PersonEntity: Name: NameFull: Pellerin, Luc – PersonEntity: Name: NameFull: Gombert, Jean-Marc – PersonEntity: Name: NameFull: Salamé, Ephrem – PersonEntity: Name: NameFull: Herbelin, André – PersonEntity: Name: NameFull: Barbier, Louise IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 05 Text: 2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 16643224 Titles: – TitleFull: Frontiers in Immunology Type: main |
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