Bibliographic Details
| Title: |
Translocation of bacterial LPS is associated with self-reported cognitive abilities in men living with HIV receiving antiretroviral therapy. |
| Authors: |
Isnard, Stéphane, Royston, Léna, Scott, Susan C., Mabanga, Tsoarello, Lin, John, Fombuena, Brandon, Bu, Simeng, Berini, Carolina A., Goldberg, Mark S., Finkelman, Malcolm, Brouillette, Marie-Josée, Fellows, Lesley K., Mayo, Nancy E., Routy, Jean-Pierre |
| Source: |
AIDS Research & Therapy; 5/18/2023, Vol. 20 Issue 1, p1-10, 10p |
| Subject Terms: |
HIV infection complications, BACTERIAL physiology, HIV infections, PROTEINS, LIPOPOLYSACCHARIDES, STATISTICS, MEN'S health, SELF-evaluation, GUT microbiome, BLOOD plasma, GLUCANS, MULTIVARIATE analysis, VIRAL load, ANTIRETROVIRAL agents, MEN, ENZYME-linked immunosorbent assay, RESEARCH funding, COGNITIVE testing, LONGITUDINAL method |
| Abstract: |
Background: Gut damage allows translocation of bacterial lipopolysaccharide (LPS) and fungal β-D-glucan (BDG) into the blood. This microbial translocation contributes to systemic inflammation and risk of non-AIDS comorbidities in people living with HIV, including those receiving antiretroviral therapy (ART). We assessed whether markers of gut damage and microbial translocation were associated with cognition in ART-treated PLWH. Methods: Eighty ART-treated men living with HIV from the Positive Brain Health Now Canadian cohort were included. Brief cognitive ability measure (B-CAM) and 20-item patient deficit questionnaire (PDQ) were administered to all participants. Three groups were selected based on their B-CAM levels. We excluded participants who received proton pump inhibitors or antiacids in the past 3 months. Cannabis users were also excluded. Plasma levels of intestinal fatty acid binding protein (I-FABP), regenerating islet-derived protein 3 α (REG3α), and lipopolysaccharides (LPS = were quantified by ELISA, while 1–3-β-D-glucan BDG) levels were assessed using the Fungitell assay. Univariable, multivariable, and splines analyses were performed. Results: Plasma levels of I-FABP, REG3α, LPS and BDG were not different between groups of low, intermediate and high B-CAM levels. However, LPS and REG3α levels were higher in participants with PDQ higher than the median. Multivariable analyses showed that LPS association with PDQ, but not B-CAM, was independent of age and level of education. I-FABP, REG3α, and BDG levels were not associated with B-CAM nor PDQ levels in multivariable analyses. Conclusion: In this well characterized cohort of ART-treated men living with HIV, bacterial but not fungal translocation was associated with presence of cognitive difficulties. These results need replication in larger samples. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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