Bibliographic Details
| Title: |
Long-lasting complete remission in a patient with systemic metastases of recurrent breast cancer treated with cyclin-dependent kinases 4/6 inhibitors: a case report. |
| Authors: |
Yoneto, Toshihiko, Hasumi, Kenichiro, Takahashi, Nobukazu, Seki, Nastuki, Takeda, Yasutaka, Yoshimoto, Takayuki |
| Source: |
Journal of Medical Case Reports; 5/9/2023, Vol. 17 Issue 1, p1-6, 6p |
| Subject Terms: |
HORMONE receptor positive breast cancer, CYCLIN-dependent kinases, MONONUCLEAR leukocytes, CANCER relapse, ASIANS, T cells |
| Abstract: |
Background: The prognosis for recurrence cases of hormone receptor-positive HER2-negative breast cancer remains poor, and treatment strategies that emphasize quality of life have often been chosen, with few physicians aiming for a cure. Our objective is to assess the validity of such current treatment strategies. Case presentation: A 74-year-old Asian woman with multiple lung and liver metastases after local recurrence of breast cancer was treated with two different cyclin-dependent kinases 4/6 inhibitors sequentially in combination with endocrine therapy. Flow cytometric analysis of the patient's peripheral blood mononuclear cells was also performed to evaluate the host's immune status. Complete remission was achieved without cytotoxic agents and the patient remains disease free to this day, 6 years after the initial relapse. Additionally, no increase in the population of the immunosenescent T cells with a phenotype of CD8+CD28− was observed in the patient's peripheral blood mononuclear cells, suggesting that the immune system was well maintained. Conclusions: We present this case study to develop new treatment strategies for recurrent breast cancer that is not only bound to misinterpretations of the Hortobagyi algorithm, but also aim for a cure with noncytotoxic agents to maintain the host's immune system and early detection of recurrence. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Medical Case Reports is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
|
Full text is not displayed to guests. |
Login for full access.
|
