Bibliographic Details
| Title: |
Association of serum level of chemerin with visceral fat obesity in type 2 diabetic patient. |
| Authors: |
Qazi, Shaheena, Siddiqui, Iftikhar Ahmed, Saeed, Muhammad, Perveen, Kahkashan, Baqa, Kulsoom, Fawwad, Asher |
| Source: |
International Journal of Diabetes in Developing Countries; Apr2023, Vol. 43 Issue 2, p298-303, 6p |
| Subject Terms: |
OBESITY risk factors, CHEMERIN, GLYCOSYLATED hemoglobin, ACADEMIC medical centers, BLOOD sugar monitoring, BLOOD sugar, TYPE 2 diabetes, RISK assessment, COMPARATIVE studies, PSYCHOSOCIAL factors, DESCRIPTIVE statistics, GLUCOSE tolerance tests, ADIPOSE tissues, PEOPLE with diabetes, PREDIABETIC state |
| Geographic Terms: |
PAKISTAN |
| Abstract: |
Aim and objective: This study aimed to investigate whether circulating chemerin levels might be associated with visceral obesity and other metabolic parameters in subject with newly diagnosed type 2 diabetes. Methodology: The study was conducted at Baqai Institute of Diabetology and Endocrinology (BIDE), Baqai Medical University (BMU), Karachi. The study was carried out after ethical approval from ethics committee of BMU. Type 2 diabetic subjects ≥ 20 years of age and without any complication were included whereas subjects with type I diabetes mellitus, gestational diabetes, and acute or chronic illness were excluded. A total of 75 subjects participated in the study and were divided into three groups, (n=25) normal glucose tolerance (NGT), (n=25) type 2 diabetes (T2DM), and (n=25) impaired glucose tolerance (IGT) according to oral glucose tolerance test (OGTT) [1]. Results: A total of 75 subjects participated in the study, out of which 25 subjects were newly diagnosed with type 2 diabetes (T2DM) and 25 subjects had impaired glucose tolerance (IGT) while 25 individuals had normal glucose tolerance (NGT). Subjects with NGT had significantly lower FBS and RBS level than subjects with IGT and T2DM. HbA1c was significantly higher in subjects with T2DM whereas chemerin level was significantly lower in T2DM as compared to subjects with NGT and IGT. Among subjects with T2DM, it was observed that only HbA1c had positively strong correlation with chemerin level (r=0.645, p=0.001) while FBS had positively moderate correlation with chemerin level (r=0.471, p=0.017). Correlation of chemerin with diastolic blood pressure, RBS, and HDL was also moderate but non-significant. Conclusion: Newly diagnosed diabetic subjects had low serum chemerin levels with obesity compared to healthy individuals, which could indicate a possibility of lifestyle modification practice in T2DM subjects. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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