| Title: |
Real-life epidemiology and current outcomes of hospitalized adults with invasive fungal infections. |
| Authors: |
Monzó-Gallo, Patricia, Chumbita, Mariana, Lopera, Carlos, Aiello, Tommaso Francesco, Peyrony, Oliver, Bodro, Marta, Herrera, Sabina, Sempere, Abiu, Fernández-Pittol, Mariana, Cuesta, Genoveva, Simó, Silvia, Benegas, Mariana, Fortuny, Claudia, Mensa, Josep, Soriano, Alex, Puerta-Alcalde, Pedro, Marco, Francesc, Garcia-Vidal, Carolina |
| Source: |
Medical Mycology; Mar2023, Vol. 61 Issue 3, p1-7, 7p |
| Abstract: |
We aimed to describe the current epidemiology of both hosts with invasive fungal infections (IFIs) and causative fungi. And, detail outcomes of these infections at 12 weeks in a real-life cohort of hospitalized patients. The study was retrospective and observational to describe IFI diagnosed in a tertiary hospital (February 2017–December 2021). We included all consecutive patients meeting criteria for proven or probable IFI according to EORTC-MSG and other criteria. A total of 367 IFIs were diagnosed. 11.7% were breakthrough infections, and 56.4% were diagnosed in the intensive care unit. Corticosteroid use (41.4%) and prior viral infection (31.3%) were the most common risk factors for IFI. Lymphoma and pneumocystis pneumonia were the most common baseline and fungal diseases. Only 12% of IFI occurred in patients with neutropenia. Fungal cultures were the most important diagnostic tests (85.8%). The most frequent IFIs were candidemia (42.2%) and invasive aspergillosis (26.7%). Azole-resistant Candida strains and non- fumigatus Aspergillus infections represented 36.1% and 44.5% of the cases, respectively. Pneumocystosis (16.9%), cryptococcosis (4.6%), and mucormycosis (2.7%) were also frequent, as well as mixed infections (3.4%). Rare fungi accounted for 9.5% of infections. Overall, IFI mortality at 12 weeks was 32.2%; higher rates were observed for Mucorales (55.6%), Fusarium (50%), and mixed infections (60%). We documented emerging changes in both hosts and real-life IFI epidemiology. Physicians should be aware of these changes to suspect infections and be aggressive in diagnoses and treatments. Currently, outcomes for such clinical scenarios remain extremely poor. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
