Bibliographic Details
| Title: |
SARS-CoV-2 Spike Protein and Neutralizing Anti-Spike Protein Antibodies Modulate Blood Platelet Function. |
| Authors: |
Luzak, Boguslawa, Rozalski, Marcin, Przygodzki, Tomasz, Boncler, Magdalena, Wojkowska, Dagmara, Kosmalski, Marcin, Watala, Cezary |
| Source: |
International Journal of Molecular Sciences; Mar2023, Vol. 24 Issue 6, p5312, 22p |
| Subject Terms: |
BLOOD platelet aggregation, BLOOD platelets, THROMBOPOIETIN receptors, BLOOD platelet activation, SARS-CoV-2, PLATELET count, COVID-19 |
| Abstract: |
Several studies report elevated blood platelet activation and altered platelet count in COVID-19 patients, but the role of the SARS-CoV-2 spike protein in this process remains intriguing. Additionally, there is no data that anti-SARS-CoV-2 neutralizing antibodies (nAb) may attenuate spike protein activity toward blood platelets. Our results indicate that under in vitro conditions, the spike protein increased the collagen-stimulated aggregation of isolated platelets and induced the binding of vWF to platelets in ristocetin-treated blood. The spike protein also significantly reduced collagen- or ADP-induced aggregation or decreased GPIIbIIIa (fibrinogen receptor) activation in whole blood, depending on the presence of the anti-spike protein nAb. Our findings suggest that studies on platelet activation/reactivity in COVID-19 patients or in donors vaccinated with anti-SARS-CoV-2 and/or previously-infected COVID-19 should be supported by measurements of spike protein and IgG anti-spike protein antibody concentrations in blood. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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