Bibliographic Details
| Title: |
Can repeated surgical resection offer a chance of cure for recurrent cholangiocarcinoma? |
| Authors: |
Laurenzi, Andrea, Brandi, Giovanni, Greco, Federica, Prosperi, Enrico, Palloni, Andrea, Serenari, Matteo, Frega, Giorgio, Ravaioli, Matteo, Rizzo, Alessandro, Cescon, Matteo |
| Source: |
Langenbeck's Archives of Surgery; Feb2023, Vol. 408 Issue 1, p1-6, 6p |
| Abstract: |
Introduction: The incidence of cholangiocarinoma (CCA), as well as the related mortality rate, has progressively increased over the last decades. Nevertheless improvement in patient management, diagnosis and therapies, recurrence rate remains high (50–70%) with a low 5-year survival (7–20%). Palliative chemotherapy and best supportive care are the treatment of choice in case of recurrence. In recent years, some reports have been published on repeated resection suggesting a survival benefit. The aim of this study was to evaluate the long-term outcome of all repeated resections for recurrent CCA in our institution. Materials and methods: We performed a retrospective analysis of all data recorded in our prospective maintained database of all patients who underwent repeated resection for recurrence of any type of CCA (intrahepatic, perihilar, distal, and gallbladder) with curative intent in our institution. Results: Between 1997 and 2017, twenty-six patients underwent repeated surgical resection for recurrent CCA. Median time to first recurrence was 20 months. Site of recurrence was liver in 18 patients (70%), lymph nodes in 6 (23%), and lungs in 2 (7%). Twenty-five patients (96%) underwent upfront surgical resection of the recurrence, while one received preoperative chemotherapy. Median overall and disease-free survival from repeated surgical resection was 21 and 18 months with a 1-, 3-, and 5-year survival of 87, 41, 29% and 75%, 27%, and 17% respectively. Five patients (21%) did not experience recurrence after repeated surgical resection after a median follow-up of 73 months. Conclusions: Repeated surgical resection of recurrent CCAs is feasible with good postoperative results and can lead to an increase in survival. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
