Bibliographic Details
| Title: |
18F‐fludeoxyglucose positron emission computed tomography (18F‐FDG‐PET/CT) versus 68Ga‐DOTATATE‐PET/CT in patients with head and neck cancer: Comparisons and implications for treatment. |
| Authors: |
Patel, Rusha, Marano, Gary, Joseph, Joe, Chung, Jeffson, Plata, Andrew, Vos, Jeffrey A. |
| Source: |
Head & Neck; Feb2023, Vol. 45 Issue 2, p347-354, 8p |
| Subject Terms: |
HEAD & neck cancer, POSITRON emission tomography, SOMATOSTATIN receptors, PAPILLOMAVIRUSES, OROPHARYNGEAL cancer |
| Abstract: |
Background: Tumor‐specific molecular imaging in head and neck squamous cell carcinoma (HNSCC) is not well established. Somatostatin receptors (SSTRs) are found in solid tumors, including HNSCC. 68Ga‐DOTATATE, a commercially available radionuclide that binds SSTRs, may have utility in imaging HNSCC. Methods: Patients with HNSCC received pretreatment imaging with 18F‐FDG‐PET/CT and 68Ga‐DOTATATE. Imaging was compared for concordance. When available, surgical resection specimens were compared to pretreatment imaging findings. Historic HNSCC tumor specimens were assessed for both SSTR and p16/human papilloma virus (HPV) expression. Results: Twenty patients were imaged. Fifteen had oropharyngeal cancer. Primary tumor site was concordant between imaging modalities for all patients. One of 45 lymph nodes was discordant. Retrospective specimen review showed a significant correlation with SSTR expression and HPV/p16 expression. No adverse events occurred. Conclusions: 68Ga‐DOTATATE imaging is safe and effective in HNSCC. SSTR expression may be increased in HPV‐mediated tumors. Targeted therapies to SSTR should be explored. [ABSTRACT FROM AUTHOR] |
|
Copyright of Head & Neck is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
