Bibliographic Details
| Title: |
The Effect of Pleural Effusion on Prognosis in Patients with Non-Small Cell Lung Cancer Undergoing Immunochemotherapy: A Retrospective Observational Study. |
| Authors: |
Nishimura, Tomoka, Ichihara, Eiki, Yokoyama, Toshihide, Inoue, Koji, Tamura, Tomoki, Sato, Ken, Oda, Naohiro, Kano, Hirohisa, Kishino, Daizo, Kawai, Haruyuki, Inoue, Masaaki, Ochi, Nobuaki, Fujimoto, Nobukazu, Ichikawa, Hirohisa, Ando, Chihiro, Hotta, Katsuyuki, Maeda, Yoshinobu, Kiura, Katsuyuki |
| Source: |
Cancers; 12/15/2022, Vol. 14 Issue 24, p6184, 10p |
| Subject Terms: |
LUNG cancer prognosis, LUNG cancer treatment, PLEURAL effusions, SCIENTIFIC observation, CONFIDENCE intervals, CANCER chemotherapy, MULTIVARIATE analysis, LOG-rank test, PROGNOSIS, RETROSPECTIVE studies, FISHER exact test, SURVIVAL analysis (Biometry), DESCRIPTIVE statistics, KAPLAN-Meier estimator, DATA analysis software, IMMUNOTHERAPY, PROPORTIONAL hazards models, DISEASE complications |
| Abstract: |
Simple Summary: Minimal data exists on pleural effusion (PE) for non-small cell lung cancer (NSCLC) patients undergoing combined ICI and chemotherapy. We retrospectively investigated how PE affects survival outcomes in patients with NSCLC undergoing this combined therapy. We identified 478 patients who underwent combined ICI therapy and chemotherapy; 357 patients did not have PE, and 121 patients did have PE. Patients with PE had significantly shorter progression-free survival and overall survival than those without PE. In addition, bevacizumab-containing regimens did not improve the survival outcomes for patients with PE. In conclusion, PE was associated with poor outcomes among patients with NSCLC undergoing combined ICI therapy and chemotherapy. Objectives: Combined immune checkpoint inhibitor (ICI) therapy and chemotherapy has become the standard treatment for advanced non-small-cell lung cancer (NSCLC). Pleural effusion (PE) is associated with poor outcomes among patients with NSCLC undergoing chemotherapy. However, minimal data exists on PE for patients undergoing combined ICI and chemotherapy. Therefore, we investigated how PE affects survival outcomes in patients with NSCLC undergoing this combined therapy. Methods: We identified patients with advanced NSCLC undergoing chemotherapy and ICI therapy from the Okayama Lung Cancer Study Group–Immune Chemotherapy Database (OLCSG–ICD) between December 2018 and December 2020; the OLCSG–ICD includes the clinical data of patients with advanced NSCLC from 13 institutions. Then, we analyzed the treatment outcomes based on the presence of PE. Results: We identified 478 patients who underwent combined ICI therapy and chemotherapy; 357 patients did not have PE, and 121 patients did have PE. Patients with PE had significantly shorter progression-free survival (PFS) and overall survival (OS) than those without PE (median PFS: 6.2 months versus 9.1 months; p < 0.001; median OS: 16.4 months versus 27.7 months; p < 0.001). The negative effect of PE differed based on the patient's programmed cell death-ligand 1 (PD-L1) expression status; with the effect being more evident in patients with high PD-L1 expression. In addition, PFS and OS did not differ between patients who did and did not undergo bevacizumab treatment; thus, bevacizumab-containing regimens did not improve the survival outcomes for patients with PE. Conclusion: PE is associated with poor outcomes among patients with NSCLC undergoing combined ICI therapy and chemotherapy. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cancers is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
|
Full text is not displayed to guests. |
Login for full access.
|
