Bibliographic Details
| Title: |
Growth Differentiation Factor 15 (GDF-15) Levels Associate with Lower Survival in Chronic Kidney Disease Patients with COVID-19. |
| Authors: |
Galassi, Andrea, Ciceri, Paola, Bono, Valeria, Magagnoli, Lorenza, Sala, Matteo, Artioli, Luisa, Rovito, Roberta, Hadla, Mohamad, Yellenki, Vaibhav, D'Arminio Monforte, Antonella, Tincati, Camilla, Cozzolino, Mario, Marchetti, Giulia |
| Source: |
Biomedicines; Dec2022, Vol. 10 Issue 12, p3251, 13p |
| Subject Terms: |
GROWTH differentiation factors, CHRONIC kidney failure, CHRONICALLY ill, COVID-19, CYTOKINE release syndrome |
| Abstract: |
A cytokine storm drives the pathogenesis of severe COVID-19 infection and several biomarkers have been linked to mortality. Chronic kidney disease (CKD) emerged as a risk factor for severe COVID-19. We investigated the association between selected biomarkers and mortality in 77 patients hospitalized for COVID-19, and whether they differ in patients with eGFR higher and lower than 45 mL/min. The association between patients' characteristics, plasma biomarkers and mortality was conducted by univariate logistic regression models and independent predictors of mortality were then used to create a multivariate prediction model through Cox regression. Patients with lower eGFR had a significant increase of GDF-15, CD-25 and RAGE, with higher plasma levels in non-survivors and in patients who needed ventilation. At univariate analysis, low and mid-low GDF-15 quartiles (<4.45 ng/mL) were associated with lower mortality risk, while mid-high and high quartiles (>4.45 ng/mL) were associated with higher mortality risk. Independent association between GDF-15 quartiles and mortality risk was confirmed in the Cox model and adjusted for eGFR, age, fever and dyspnea (HR 2.28, CI 1.53–3.39, p < 0.0001). The strength of the association between GDF-15 quartiles and mortality risk increased in patients with lower compared to higher eGFR (HR 2.53, CI 1.34–4.79 versus HR 1.99, CI 1.17–3.39). Our findings may suggest a further investigation of the effect of GDF-15 signaling pathway inhibition in CKD. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
