Bibliographic Details
| Title: |
Evaluation of SI, MSI and DSI for very early (3-day) mortality in patients with septic shock. |
| Authors: |
Zhang, Tie-Ning, Hao, Peng-Hui, Gao, Shan-Yan, Liu, Chun-Feng, Yang, Ni |
| Source: |
European Journal of Medical Research; 11/3/2022, Vol. 27 Issue 1, p1-10, 10p |
| Subject Terms: |
SEPTIC shock, INTENSIVE care patients, LOGISTIC regression analysis, RECEIVER operating characteristic curves, HOSPITAL mortality |
| Abstract: |
Background: Septic shock is associated with increased mortality. Predicting mortality, including early prediction for septic shock patients in intensive care units (ICUs), remains an important challenge. Method: We searched the Medical Information Mart for Intensive Care IV database. Odds ratios (ORs) with 95% confidence intervals (CIs) of the relationships between shock index (SI), modified SI (MSI), and diastolic SI (DSI) of patients with septic shock requiring vasopressors and 3-day/in-hospital mortality were calculated using logistic regression models. The time-course changes of these parameters were compared between survivors and non-survivors. The performance of the different parameters was described by the area under the receiver operating characteristic (ROC) curve (AUC) and compared with DeLong analysis. Results: A total of 1266 patients with septic shock requiring vasopressors were identified. The 3-day mortality rate and in-hospital mortality rate were 8.7% and 23.5%, respectively. Multivariable logistic regression analysis showed significant associations between pre-vasopressor SI/MSI/DSI and 3-day mortality in patients with septic shock requiring vasopressors in fully adjusted models (Ps for trend < 0.01). The AUCs of pre-vasopressor SI, MSI, and DSI were 0.746, 0.710, and 0.732 for 3-day mortality, respectively. There were significant differences in the time-course of SI, MSI, and DSI between survivors and non-survivors at 3-day/in-hospital mortality among patients with septic shock requiring vasopressors (repeated-measures ANOVA, inter-subjects difference P < 0.001). Conclusion: Pre-vasopressor SI, MSI, and DSI values identified patients with septic shock requiring vasopressors who are at increased risk of early death. Of these easy-to-acquire values, SI and MSI show a comparatively better performance. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
