Bibliographic Details
| Title: |
SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell model. |
| Authors: |
Mache, Christin, Schulze, Jessica, Holland, Gudrun, Bourquain, Daniel, Gensch, Jean-Marc, Oh, Djin-Ye, Nitsche, Andreas, Dürrwald, Ralf, Laue, Michael, Wolff, Thorsten |
| Source: |
Communications Biology; 10/27/2022, Vol. 5 Issue 1, p1-8, 8p |
| Subject Terms: |
SARS-CoV-2 Omicron variant, LUNGS, CORONAVIRUS diseases, RESPIRATORY infections, SARS-CoV-2 Delta variant, EPITHELIAL cells, VIRUS diseases, INFLUENZA viruses |
| Abstract: |
SARS-CoV-2 and its emerging variants of concern remain a major threat for global health. Here we introduce an infection model based upon polarized human Alveolar Epithelial Lentivirus immortalized (hAELVi) cells grown at the air–liquid interface to estimate replication and epidemic potential of respiratory viruses in the human lower respiratory tract. hAELVI cultures are highly permissive for different human coronaviruses and seasonal influenza A virus and upregulate various mediators following virus infection. Our analysis revealed a significantly reduced capacity of SARS-CoV-2 Omicron BA.1 and BA.2 variants to propagate in this human model compared to earlier D614G and Delta variants, which extends early risk assessments from epidemiological and animal studies suggesting a reduced pathogenicity of Omicron. Human alveolar epithelial lentivirus immortalized cells are very permissive for human coronaviruses and influenza A viruses, provided a suitable model for such infections of the lower respiratory tract as shown by reduced propagation of the SARS-CoV-2 Omicron variant. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
