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Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy.

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Title: Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy.
Authors: Siopi, Maria, Papadopoulos, Antonios, Spiliopoulou, Anastasia, Paliogianni, Fotini, Abou-Chakra, Nissrine, Arendrup, Maiken Cavling, Damoulari, Christina, Tsioulos, Georgios, Giannitsioti, Efthymia, Frantzeskaki, Frantzeska, Tsangaris, Iraklis, Pournaras, Spyros, Meletiadis, Joseph
Source: Journal of Fungi; Sep2022, Vol. 8 Issue 9, pN.PAG-N.PAG, 7p
Subject Terms: CASPOFUNGIN, ECHINOCANDINS, CANDIDEMIA, CANDIDA, URINE, PATIENTS
Abstract: The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Fungi is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Group: Ti
  Data: Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy.
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  Data: <searchLink fieldCode="AR" term="%22Siopi%2C+Maria%22">Siopi, Maria</searchLink><br /><searchLink fieldCode="AR" term="%22Papadopoulos%2C+Antonios%22">Papadopoulos, Antonios</searchLink><br /><searchLink fieldCode="AR" term="%22Spiliopoulou%2C+Anastasia%22">Spiliopoulou, Anastasia</searchLink><br /><searchLink fieldCode="AR" term="%22Paliogianni%2C+Fotini%22">Paliogianni, Fotini</searchLink><br /><searchLink fieldCode="AR" term="%22Abou-Chakra%2C+Nissrine%22">Abou-Chakra, Nissrine</searchLink><br /><searchLink fieldCode="AR" term="%22Arendrup%2C+Maiken+Cavling%22">Arendrup, Maiken Cavling</searchLink><br /><searchLink fieldCode="AR" term="%22Damoulari%2C+Christina%22">Damoulari, Christina</searchLink><br /><searchLink fieldCode="AR" term="%22Tsioulos%2C+Georgios%22">Tsioulos, Georgios</searchLink><br /><searchLink fieldCode="AR" term="%22Giannitsioti%2C+Efthymia%22">Giannitsioti, Efthymia</searchLink><br /><searchLink fieldCode="AR" term="%22Frantzeskaki%2C+Frantzeska%22">Frantzeskaki, Frantzeska</searchLink><br /><searchLink fieldCode="AR" term="%22Tsangaris%2C+Iraklis%22">Tsangaris, Iraklis</searchLink><br /><searchLink fieldCode="AR" term="%22Pournaras%2C+Spyros%22">Pournaras, Spyros</searchLink><br /><searchLink fieldCode="AR" term="%22Meletiadis%2C+Joseph%22">Meletiadis, Joseph</searchLink>
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  Data: Journal of Fungi; Sep2022, Vol. 8 Issue 9, pN.PAG-N.PAG, 7p
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  Data: <searchLink fieldCode="DE" term="%22CASPOFUNGIN%22">CASPOFUNGIN</searchLink><br /><searchLink fieldCode="DE" term="%22ECHINOCANDINS%22">ECHINOCANDINS</searchLink><br /><searchLink fieldCode="DE" term="%22CANDIDEMIA%22">CANDIDEMIA</searchLink><br /><searchLink fieldCode="DE" term="%22CANDIDA%22">CANDIDA</searchLink><br /><searchLink fieldCode="DE" term="%22URINE%22">URINE</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENTS%22">PATIENTS</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Fungi is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.3390/jof8090931
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: N.PAG
    Subjects:
      – SubjectFull: CASPOFUNGIN
        Type: general
      – SubjectFull: ECHINOCANDINS
        Type: general
      – SubjectFull: CANDIDEMIA
        Type: general
      – SubjectFull: CANDIDA
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      – SubjectFull: URINE
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      – SubjectFull: PATIENTS
        Type: general
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      – TitleFull: Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy.
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            – D: 01
              M: 09
              Text: Sep2022
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