Bibliographic Details
| Title: |
Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy. |
| Authors: |
Siopi, Maria, Papadopoulos, Antonios, Spiliopoulou, Anastasia, Paliogianni, Fotini, Abou-Chakra, Nissrine, Arendrup, Maiken Cavling, Damoulari, Christina, Tsioulos, Georgios, Giannitsioti, Efthymia, Frantzeskaki, Frantzeska, Tsangaris, Iraklis, Pournaras, Spyros, Meletiadis, Joseph |
| Source: |
Journal of Fungi; Sep2022, Vol. 8 Issue 9, pN.PAG-N.PAG, 7p |
| Subject Terms: |
CASPOFUNGIN, ECHINOCANDINS, CANDIDEMIA, CANDIDA, URINE, PATIENTS |
| Abstract: |
The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
