Bibliographic Details
| Title: |
The Effect of Noise Trauma and Deep Brain Stimulation of the Medial Geniculate Body on Tissue Activity in the Auditory Pathway. |
| Authors: |
Almasabi, Faris, van Zwieten, Gusta, Alosaimi, Faisal, Smit, Jasper V., Temel, Yasin, Janssen, Marcus L. F., Jahanshahi, Ali |
| Source: |
Brain Sciences (2076-3425); Aug2022, Vol. 12 Issue 8, p1099, 12p |
| Subject Terms: |
DEEP brain stimulation, AUDITORY pathways, THALAMIC nuclei, BRAIN injuries, AUDITORY cortex, CYTOCHROME oxidase, AUDITORY perception |
| Abstract: |
Tinnitus is defined as the phantom perception of sound. To date, there is no curative treatment, and contemporary treatments have failed to show beneficial outcomes. Deep brain stimulation has been suggested as a potential therapy for refractory tinnitus. However, the optimal target and stimulation regimens remain to be defined. Herein, we investigated metabolic and neuronal activity changes using cytochrome C oxidase histochemistry and c-Fos immunohistochemistry in a noise trauma-induced rat model of tinnitus. We also assessed changes in neuronal activity following medial geniculate body (MGB) high-frequency stimulation (HFS). Metabolic activity was reduced in the primary auditory cortex, MGB and CA1 region of the hippocampus in noise-exposed rats. Additionally, c-Fos expression was increased in the primary auditory cortex of those animals. Furthermore, MGB-HFS enhanced c-Fos expression in the thalamic reticular nucleus. We concluded that noise trauma alters tissue activity in multiple brain areas including the auditory and limbic regions. MGB-HFS resulted in higher neuronal activity in the thalamic reticular nucleus. Given the prominent role of the auditory thalamus in tinnitus, these data provide more rationales towards targeting the MGB with HFS as a symptom management tool in tinnitus. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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