Bibliographic Details
| Title: |
Diabetic kidney disease versus non‐diabetic kidney disease in type 2 diabetic patients on dialysis: An observational cohort. |
| Authors: |
Delautre, Arnaud, Hannedouche, Thierry, Couchoud, Cécile, Guiserix, José, Cerasuolo, Damiano, Chantrel, François, Martzloff, Jonas, Keller, Nicolas, Krummel, Thierry |
| Source: |
Endocrinology, Diabetes & Metabolism; Jul2022, Vol. 5 Issue 4, p1-9, 9p |
| Subject Terms: |
DIABETIC nephropathies, PEOPLE with diabetes, HEMODIALYSIS patients, KIDNEY diseases, MAJOR adverse cardiovascular events, KIDNEYS, CHRONIC kidney failure |
| Abstract: |
Background: All chronic kidney diseases in diabetic patients are not diabetic kidney diseases. The objective was to compare the clinical characteristics, survival and access to transplantation in diabetic patients starting dialysis and classified either as diabetic kidney disease (DKD) or non‐diabetic kidney disease in diabetic patients (NDKD). Methods: We used the nationwide French REIN registry to analyse baseline clinical characteristics at dialysis inception and outcomes defined as kidney transplantation, deaths and their causes. The probability of death or transplantation was analysed using a multivariate Cox model and the Fine and Gray competing for risk model (sdHT). Results: We included 65,136 patients from January 2009 to December 2015 with a median follow‐up of 31 months. The cumulative incidence of kidney transplantation over eight years was 46.9% (44.8–48.9) in non‐diabetic patients (ND), higher than the 19.3% (17.5–21.2) in the DKD group and 22.2% (18.4–26.7) in the NDKD group. The risk of death was significantly higher in the NDKD group than in the DKD group, even after accounting for the competing risk of transplantation (NDKD/sdHR 1.22; 95%CI 1.18–1.27; p < 0.005 vs. DKD/sdHR 1.12; 95%CI 1.08–1.16; p < 0.005 with adjustment for age, sex, major adverse cardiovascular events, cancer and chronic respiratory failure, compared to ND). Conclusions: In diabetic patients starting dialysis, patients in the DKD group had reduced access to kidney transplantation. NDKD patients had a higher risk of mortality than DKD. The distinction between DKD and NDKD should be accounted for in the plan of care of diabetic patients starting dialysis. [ABSTRACT FROM AUTHOR] |
|
Copyright of Endocrinology, Diabetes & Metabolism is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
