Bibliographic Details
| Title: |
Maternal diabetes independent of BMI is associated with altered accretion of adipose tissue in large for gestational age fetuses. |
| Authors: |
Lam, Penny, Mein, Brendan J., Benzie, Ronald J., Ormerod, John T., Robledo, Kristy P., Hibbert, Emily J., Nanan, Ralph K. |
| Source: |
PLoS ONE; 5/31/2022, Vol. 17 Issue 5, p1-13, 13p |
| Subject Terms: |
GESTATIONAL age, FETUS, ADIPOSE tissues, GESTATIONAL diabetes, BODY mass index, ABDOMINAL adipose tissue |
| Abstract: |
Aim: To analyse the effects of maternal diabetes mellitus (DM) and body mass Index (BMI) on central and peripheral fat accretion of large for gestational age (LGA) offspring. Methods: This retrospective study included LGA fetuses (n = 595) with ultrasound scans at early (19.23 ± 0.68 weeks), mid (28.98 ± 1.62 weeks) and late (36.20 ± 1.59 weeks) stages of adipogenesis and measured abdominal (AFT) and mid-thigh (TFT) fat as surrogates for central and peripheral adiposity. Women were categorised according to BMI and DM status [pre-gestational (P-DM; n = 59), insulin managed (I-GDM; n = 132) and diet managed gestational diabetes (D-GDM; n = 29)]. Analysis of variance and linear regressions were applied. Results: AFT and TFT did not differ significantly between BMI categories (normal, overweight and obese). In contrast, AFT was significantly higher in pregnancies affected by D-GDM compared to non-DM pregnancies from mid stage (0.44 mm difference, p = 0.002) and for all DM categories in late stage of adipogenesis (≥ 0.49 mm difference, p < 0.008). Late stage TFT accretion was higher than controls for P-DM and I-GDM but not for D-GDM (0.67 mm difference, p < 0.001; 0.49 mm difference, p = 0.001, 0.56 mm difference, p = 0.22 respectively). In comparison to the early non-DM group with an AFT to TFT ratio of 1.07, the I-GDM group ratio was 1.25 (p < 0.001), which normalised by 28 weeks becoming similar to control ratios. Conclusions: DM, independent of BMI, was associated with higher abdominal and mid-thigh fat accretion in fetuses. Use of insulin improved central to peripheral fat ratios in fetuses of GDM mothers. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
