Bibliographic Details
| Title: |
The impact of pertussis vaccine programme changes on pertussis disease burden in Manitoba, 1992-2017-an age-period-cohort analysis. |
| Authors: |
Wilkinson, Krista, Righolt, Christiaan H, Elliott, Lawrence J, Fanella, Sergio, Mahmud, Salaheddin M |
| Source: |
International Journal of Epidemiology; Apr2022, Vol. 51 Issue 2, p440-447, 8p |
| Subject Terms: |
IMMUNIZATION, DISEASE incidence, WHOOPING cough, IMPACT of Event Scale, RESEARCH funding, WHOOPING cough vaccines, ECONOMIC aspects of diseases, LONGITUDINAL method |
| Geographic Terms: |
MANITOBA |
| Abstract: |
Background: Changes to pertussis vaccination programmes can have impacts on disease burden that should be estimated independently from factors such as age- and period-related trends. We used age-period-cohort (APC) models to explore pertussis incidence in Manitoba over a 25-year period (1992-2017).Methods: We identified all laboratory-confirmed cases of pertussis from Manitoba's Communicable Diseases Database and calculated age-standardized incidence rates. We used APC models to investigate trends in pertussis incidence.Results: During the study period, 2479 cases were reported. Age-standardized rates were highest during a large outbreak in 1994 (55 cases/100 000 person-years), with much lower peaks in 1998, 2012 and 2016. We saw strong age and cohort effects in the APC models, with a steady decrease in incidence with increasing age and increased risk in the cohort born between 1980 and 1995.Conclusions: The highest risk for pertussis was consistently in young children, regardless of birth cohort or time period. The 1981 programme change to an adsorbed whole-cell pertussis vaccine with low effectiveness resulted in reduced protection in the 1981-95 birth cohort and contributed to the largest outbreak of disease during the 25-year study period. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
