| Title: |
Perillyl alcohol and its synthetic derivatives: the rising of a novel class of selective and potent antitumoral compounds. |
| Authors: |
Lessa, Renato C. S., Gomes, Aline C. C. A. |
| Source: |
Medicinal Chemistry Research; May2022, Vol. 31 Issue 5, p677-694, 18p |
| Abstract: |
(S)-(-)-perillyl alcohol (POH) is a natural occurrence monoterpene that can be found in specific plants' essential oil. Despite its poor bioavailability when orally administered, due to fast metabolization through P450 enzyme oxidation, inhalation unveiled its selective cytotoxicity for glioma cells. Actually, under phase I/II clinical trial for glioblastoma multiforme (GBM) treatment at Hospital Universitário Antônio Pedro (HUAP) in Brazil, POH became a potential lead compound for developing novel antitumoral drugs. Recent reports highlight POH potential as a chemosensitizing agent, describes efficient novel derivatives for topical administration in multiple myeloma treatment and unveils its effectivity against different chemoresistant cancer cell lines. In this review, POH and its synthetical derivatives will be presented reporting its potential as a valuable scaffold to develop novel selective antitumoral agents. A summarized biological and mechanistic approach is also discussed. Only selected synthetic procedures are presented to keep the article in a reader-friendly fashion. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
