| Title: |
Magnetic Resonance-Guided Reirradiation for Local Recurrence within the Prostate or in the Prostate Bed: One-Year Clinical Results of a Prospective Registry Study. |
| Authors: |
Michalet, Morgan, Riou, Olivier, Cottet-Moine, Jeremy, Castan, Florence, Gourgou, Sophie, Valdenaire, Simon, Debuire, Pierre, Ailleres, Norbert, Draghici, Roxana, Charissoux, Marie, Llacer Moscardo, Carmen, Farcy-Jacquet, Marie-Pierre, Fenoglietto, Pascal, Azria, David |
| Source: |
Cancers; Apr2022, Vol. 14 Issue 8, p1943, 14p |
| Subject Terms: |
MAGNETIC resonance imaging, CANCER relapse, PHARMACEUTICAL arithmetic, DESCRIPTIVE statistics, KAPLAN-Meier estimator, RADIOTHERAPY, RADIOSURGERY, RADIOISOTOPE brachytherapy, PROSTATE tumors, LONGITUDINAL method |
| Abstract: |
Simple Summary: MRI-guided radiotherapy (MRgRT) is a new technique of radiotherapy. We evaluated this treatment for the reirradiation of patients with local-only recurrence of prostate cancers. The objectives were to evaluate the tolerance and the first clinical results in a cohort of 37 patients with a 1-year follow-up. The treatment was well tolerated with no grade > 2 acute toxicities and only one (3%) grade 3 late toxicity (hematuria). The clinical results were promising with a six, nine and 12-months biochemical-recurrence free survival of 97.3%, 86.5% and 65.0%, respectively. In conclusion, MRI-guided reirradiation might become an interesting option for the treatment of locally recurrent prostate cancers. Around 33% of patients treated by EBRT or brachytherapy will present a biochemical recurrence. SBRT is a new option for the treatment of patients with local-only recurrence. MRgRT seems to be interesting for the treatment of these recurrences. This article presents the one-year late tolerance and biochemical recurrence-free survival results of a prospective registry study. Patients with intraprostatic (or in the prostate bed) recurrence were treated with 5 to 9 fractions (median dose of 30 Gy in 5 fractions) with the MRIdian® system. PSA level and toxicities were evaluated before treatment and at three, six and 12 months after treatment. Thirty-seven patients with a median age of 74.5 years old were treated between 21 October 2019 and 7 December 2020. Acute tolerance was excellent with no grade >2 toxicities. Twelve months after treatment, we observed an increase of grade 1–2 dysuria (46% vs. 13% before treatment) and grade 1 polyuria (73% vs. 7%). The six, nine and 12-months biochemical-recurrence free survival were 97.3%, 86.5% and 65.0%. Fifteen patients (40%) presented a biochemical recurrence. Nine of these 15 patients (60%) had a persistent disease within the treated volume. In conclusion, MRgRT is safe and has promising survival results. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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