Bibliographic Details
| Title: |
Long-Term Cognitive Decline Related to the Motor Phenotype in Parkinson's Disease. |
| Authors: |
Michels, Jennifer, van der Wurp, Hendrik, Kalbe, Elke, Rehberg, Sarah, Storch, Alexander, Linse, Katharina, Schneider, Christine, Gräber, Susanne, Berg, Daniela, Dams, Judith, Balzer-Geldsetzer, Monika, Hilker-Roggendorf, Rüdiger, Oberschmidt, Carola, Baudrexel, Simon, Witt, Karsten, Schmidt, Nele, Deuschl, Günther, Mollenhauer, Brit, Trenkwalder, Claudia, Liepelt-Scarfone, Inga |
| Source: |
Journal of Parkinson's Disease; 2022, Vol. 12 Issue 3, p905-916, 12p |
| Subject Terms: |
PARKINSON'S disease, COGNITION disorders, GAIT disorders, SYMPTOMS, APATHY, COGNITION |
| Abstract: |
Background: Parkinson's disease (PD) is associated with various non-motor symptoms, including cognitive deterioration. Objective: Here, we used data from the DEMPARK/LANDSCAPE cohort to describe the association between progression of cognitive profiles and the PD motor phenotypes: postural instability and gait disorder (PIGD), tremor-dominant (TR-D), and not-determined (ND). Methods: Demographic, clinical, and neuropsychological six-year longitudinal data of 711 PD-patients were included (age: M = 67.57; 67.4% males). We computed z-transformed composite scores for a priori defined cognitive domains. Analyses were controlled for age, gender, education, and disease duration. To minimize missing data and drop-outs, three-year follow-up data of 442 PD-patients was assessed with regard to the specific role of motor phenotype on cognitive decline using linear mixed modelling (age: M = 66.10; 68.6% males). Results: Our study showed that in the course of the disease motor symptoms increased while MMSE and PANDA remained stable in all subgroups. After three-year follow-up, significant decline of overall cognitive performance for PIGD-patients were present and we found differences for motor phenotypes in attention (β= –0.08, SE = 0.003, p < 0.006) and memory functions showing that PIGD-patients deteriorate per months by –0.006 compared to the ND-group (SE = 0.003, p = 0.046). Furthermore, PIGD-patients experienced more often difficulties in daily living. Conclusion: Over a period of three years, we identified distinct neuropsychological progression patterns with respect to different PD motor phenotypes, with early executive deficits yielding to a more amnestic profile in the later course. Here, in particular PIGD-patients worsened over time compared to TR-D and ND-patients, highlighting the greater risk of dementia for this motor phenotype. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Parkinson's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
