Bibliographic Details
| Title: |
Urinary sulphated glycosaminoglycans excretion in obese patients with type 2 diabetes mellitus treated with metformin. |
| Authors: |
Jura-Półtorak, Agnieszka, Olczyk, Paweł, Chałas-Lipka, Aleksandra, Komosińska-Vassev, Katarzyna, Kuźnik-Trocha, Kornelia, Winsz-Szczotka, Katarzyna, Ivanova, Diana, Kiselova-Kaneva, Yoana, Krysik, Katarzyna, Telega, Alicja, Olczyk, Krystyna |
| Source: |
Archives of Physiology & Biochemistry; Apr2022, Vol. 128 Issue 2, p507-513, 7p |
| Subject Terms: |
METFORMIN, TYPE 2 diabetes, GLYCOSAMINOGLYCANS, DERMATAN sulfate, EXCRETION, CHONDROITIN, OBESITY |
| Abstract: |
The pattern of urinary excretion of total sulphated glycosaminoglycans (GAGs) and their particular types: chondroitin sulphate/dermatan sulphate (CS/DS) and heparan sulphate (HS) was analysed in obese patients with type 2 diabetes mellitus (T2DM) treated with metformin in monotherapy for the period of six months. The urinary sulphated glycosaminoglycans were quantitated using standardised dye (1.9-dimethylmethylene blue)-binding method and normalised to creatinine level. Urinary total GAGs, CS/DS and HS levels were significantly higher in untreated diabetic patients in comparison to healthy subjects. Moreover, it was observed that urinary total GAGs, CS/DS and HS levels in diabetic patients after six-month metformin therapy were significantly decreased versus pre-treatment situation. The obtained results suggest that the six-month treatment with metformin in obese patients with T2DM has a regulating influence on the systemic changes in proteoglycans/glycosaminoglycans, resulting in a decrease in the urinary excretion of total GAGs, CS/DS and HS. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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