Bibliographic Details
| Title: |
Landscape of Candidemia During the Coronavirus Disease 2019 (COVID-19) Pandemic. |
| Authors: |
Seagle, Emma E, Jackson, Brendan R, Lockhart, Shawn R, Georgacopoulos, Ourania, Nunnally, Natalie S, Roland, Jeremy, Barter, Devra M, Johnston, Helen L, Czaja, Christopher A, Kayalioglu, Hazal, Clogher, Paula, Revis, Andrew, Farley, Monica M, Harrison, Lee H, Davis, Sarah Shrum, Phipps, Erin C, Tesini, Brenda L, Schaffner, William, Markus, Tiffanie M, Lyman, Meghan M |
| Source: |
Clinical Infectious Diseases; Mar2022, Vol. 74 Issue 5, p802-811, 10p |
| Subject Terms: |
PUBLIC health surveillance, INTENSIVE care units, ADRENOCORTICAL hormones, CENTRAL venous catheterization, FISHER exact test, RISK assessment, LIVER diseases, ARTIFICIAL respiration, HOSPITAL mortality, DESCRIPTIVE statistics, CHI-squared test, IMMUNOSUPPRESSIVE agents, COVID-19 pandemic, CANDIDEMIA, DISEASE risk factors, DISEASE complications |
| Geographic Terms: |
GEORGIA |
| Abstract: |
Background The COVID-19 pandemic has resulted in unprecedented healthcare challenges, and COVID-19 has been linked to secondary infections. Candidemia, a fungal healthcare-associated infection, has been described in patients hospitalized with severe COVID-19. However, studies of candidemia and COVID-19 coinfection have been limited in sample size and geographic scope. We assessed differences in patients with candidemia with and without a COVID-19 diagnosis. Methods We conducted a case-level analysis using population-based candidemia surveillance data collected through the Centers for Disease Control and Prevention's Emerging Infections Program during April–August 2020 to compare characteristics of candidemia patients with and without a positive test for COVID-19 in the 30 days before their Candida culture using chi-square or Fisher's exact tests. Results Of the 251 candidemia patients included, 64 (25.5%) were positive for SARS-CoV-2. Liver disease, solid-organ malignancies, and prior surgeries were each >3 times more common in patients without COVID-19 coinfection, whereas intensive care unit–level care, mechanical ventilation, having a central venous catheter, and receipt of corticosteroids and immunosuppressants were each >1.3 times more common in patients with COVID-19. All-cause in-hospital fatality was 2 times higher among those with COVID-19 (62.5%) than without (32.1%). Conclusions One-quarter of candidemia patients had COVID-19. These patients were less likely to have certain underlying conditions and recent surgery commonly associated with candidemia and more likely to have acute risk factors linked to COVID-19 care, including immunosuppressive medications. Given the high mortality, it is important for clinicians to remain vigilant and take proactive measures to prevent candidemia in patients with COVID-19. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
