Bibliographic Details
| Title: |
MANGOSTEEN RIND EXTRACT NANO-EMULSION AS MUCOADHESIVE GINGIVAL PATCH EFFECT ON OSTEOBLAST AND OSTEOCLAST NUMBERS IN PERIODONTITIS INDUCED WISTAR RATS. |
| Authors: |
Sidarningsih, Qaid, Huda Rashad, Ramadhani, Yeka, Putri Rahmasari, Riski Rahayu, Maksum, Mohammad Ali, Ramadhani, Afrida Fania, Nabilla, Jihan Hijriya, Diyatri, Indeswati, Ridwan, Rini Devijanti |
| Source: |
Biochemical & Cellular Archives; Oct2021, Vol. 21 Issue 2, p3273-3278, 6p |
| Subject Terms: |
PERIODONTITIS treatment, LABORATORY rats, MANGOSTEEN, HEMATOXYLIN & eosin staining, OSTEOBLASTS |
| Abstract: |
Nano-emulsion is an advanced form of nanotechnology-based drug delivery systems aiming to deliver the antibacterial agent of mangosteen for periodontitis treatment. The aim of this study was to investigate that nano-emulsion of mangosteen rind extract and mangosteen rind extract in a mucoadhesive gingival patch related to its therapeutic potency on periodontitis induced Wistar Rats. A laboratory experimental research with a post-test only control group was conducted using 60 Wistar rats divided into 4 groups: control positive group (doxycycline in a mucoadhesive patch application), control negative group (mucoadhesive patch application), the treatment group I (mangosteen rind extract in a mucoadhesive patch application), and the treatment group II (nano-emulsion of mangosteen rind extract in a mucoadhesive patch application). The induction of bacteria P. gingivalis 1 X 1010 CFU as much as 0.03ml was injected once at 2-days intervals for 14 days. The application of treatment was for 1 hour/day for 7 days. Moreover, five rats from each group would be sacrificed on Day 3, 5 and 7 after the application of treatment. hematoxylin eosin examination to determine the number of osteoblasts and osteoclasts. Mucoadhesive patch of nano-emulsion mangosteen peel extract can reduce the number of osteoclasts and increase the number of osteoblasts on Day 3 but decline on day 5 and 7. In conclusion, mangosteen rind extract nano emulsion as mucoadhesive gingival patch can inhibit alveolar bone damage by enhance of osteoblast and decrease osteoclast numbers in periodontitis induce wistar rats. [ABSTRACT FROM AUTHOR] |
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Copyright of Biochemical & Cellular Archives is the property of Dr. P.R. Yadav and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
