Bibliographic Details
| Title: |
Myeloid-Derived Suppressor Cells in Prostate Cancer: Present Knowledge and Future Perspectives. |
| Authors: |
Koinis, Filippos, Xagara, Anastasia, Chantzara, Evangelia, Leontopoulou, Vassiliki, Aidarinis, Chrissovalantis, Kotsakis, Athanasios |
| Source: |
Cells (2073-4409); Jan2022, Vol. 11 Issue 1, p20, 1p |
| Subject Terms: |
MYELOID-derived suppressor cells, PROSTATE cancer, CANCER cells, IMMUNE response, IMMUNE checkpoint proteins |
| Abstract: |
Several lines of research are being investigated to better understand mechanisms implicated in response or resistance to immune checkpoint blockade in prostate cancer (PCa). Myeloid-derived suppressor cells (MDSCs) have emerged as a major mediator of immunosuppression in the tumor microenvironment that promotes progression of various tumor types. The main mechanisms underlying MDSC-induced immunosuppression are currently being explored and strategies to enhance anti-tumor immune response via MDSC targeting are being tested. However, the role of MDSCs in PCa remains elusive. In this review, we aim to summarize and present the state-of-the-art knowledge on current methodologies to phenotypically and metabolically characterize MDSCs in PCa. We describe how these characteristics may be linked with MDSC function and may influence the clinical outcomes of patients with PCa. Finally, we briefly discuss emerging strategies being employed to therapeutically target MDSCs and potentiate the long-overdue improvement in the efficacy of immunotherapy in patients with PCa. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cells (2073-4409) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
|
Full text is not displayed to guests. |
Login for full access.
|
