Bibliographic Details
| Title: |
Not just "leuko" after all: Epithelial leukotriene production in type 2 immunity. |
| Authors: |
Henkel, Fiona D. R., Bieren, Julia Esser-von |
| Source: |
Science Immunology; 2022, Vol. 7 Issue 67, p1-3, 3p |
| Subject Terms: |
NEMATODE infections, IMMUNITY, LEUKOTRIENES, TRP channels, OXYGENASES, LIQUID chromatography-mass spectrometry |
| Abstract: |
Albeit showing abrogated airway tuft cell expansion in I Ltc4s i SP -/- sp mice ([8]), the authors' previous work does not provide direct proof for airway tuft cells as the source of CysLTs during I Alternaria i -induced type 2 airway inflammation. N. brasiliensis infection causes tuft cell hyperplasia, whereas H. polygyrus products reverse tuft cell expansion. Although tuft cell-derived CysLTs are implicated in early innate type 2 immune responses, it is unclear what the relative contribution of tuft cell CysLTs in chronic type 2 inflammation is, e.g., in allergic asthma or nasal polyposis. A lack of CysLT synthesis in tuft cells abrogates allergen-induced tuft cell expansion and attenuates ILC2 and eosinophil responses, demonstrating both autocrine and paracrine functions of tuft cell-derived CysLTs. [Extracted from the article] |
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| Database: |
Complementary Index |
