| Title: |
Molecular Remodeling of Cardiac Sinus Node Associated with Acute Chagas Disease Myocarditis. |
| Authors: |
Rodríguez-Angulo, Héctor O., Colombet-Naranjo, Diana, Maza, María C., Poveda, Cristina, Herreros-Cabello, Alfonso, Mendoza, Iván, Perera, Juan C., Goyo, Juan D., Gironès, Núria, Fresno, Manuel |
| Source: |
Microorganisms; Nov2021, Vol. 9 Issue 11, p2208-2208, 1p |
| Subject Terms: |
CHAGAS' disease, ARRHYTHMIA, SINOATRIAL node, ACUTE diseases, HEART failure, VENTRICULAR arrhythmia |
| Abstract: |
Chagas disease principally affects Latin-American people, but it currently has worldwide distribution due to migration. Death among those with Chagas disease can occur suddenly and without warning, even in those who may not have evidence of clinical or structural cardiac disease and who are younger than 60 years old. HCN4 channels, one of the principal elements responsible for pacemaker currents, are associated with cardiac fetal reprogramming and supraventricular and ventricular arrhythmias, but their role in chagasic arrhythmias is not clear. We found that a single-dose administration of ivabradine, which blocks HCN4, caused QTc and QRS enlargement and an increase in P-wave amplitude and was associated with ventricular and supraventricular arrhythmias in mice challenged with isoproterenol, a chronotropic/ionotropic positive agent. Continuous treatment with ivabradine did not alter the QTc interval, but P-wave morphology was deeply modified, generating supraventricular arrhythmias. In addition, we found that repolarization parameters improved with ivabradine treatment. These effects could have been caused by the high HCN4 expression observed in auricular and ventricular tissue in infected mice. Thus, we suggest, for the first time, that molecular remodeling by overexpression of HCN4 channels may be related to supraventricular arrhythmias in acute Chagas disease, causing ivabradine over-response. Thus, ivabradine treatment should be administered with caution, while HCN4 overexpression may be an indicator of heart failure and/or sudden death risk. [ABSTRACT FROM AUTHOR] |
|
Copyright of Microorganisms is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
