Bibliographic Details
| Title: |
Regeneration of Bone Defects in a Rabbit Femoral Osteonecrosis Model Using 3D-Printed Poly (Epsilon-Caprolactone)/Nanoparticulate Willemite Composite Scaffolds. |
| Authors: |
Karimzadeh Bardeei, Latifeh, Seyedjafari, Ehsan, Hossein, Ghamartaj, Nabiuni, Mohammad, Majles Ara, Mohammad Hosein, Salber, Jochen |
| Source: |
International Journal of Molecular Sciences; Oct2021, Vol. 22 Issue 19, p10332, 1p |
| Subject Terms: |
BONE regeneration, POLYCAPROLACTONE, OSTEONECROSIS, BONE marrow cells, BONE substitutes, CYTOCOMPATIBILITY, FEMUR head |
| Abstract: |
Steroid-associated osteonecrosis (SAON) is a chronic disease that leads to the destruction and collapse of bone near the joint that is subjected to weight bearing, ultimately resulting in a loss of hip and knee function. Zn2+ ions, as an essential trace element, have functional roles in improving the immunophysiological cellular environment, accelerating bone regeneration, and inhibiting biofilm formation. In this study, we reconstruct SAON lesions with a three-dimensional (3D)-a printed composite made of poly (epsilon-caprolactone) (PCL) and nanoparticulate Willemite (npW). Rabbit bone marrow stem cells were used to evaluate the cytocompatibility and osteogenic differentiation capability of the PCL/npW composite scaffolds. The 2-month bone regeneration was assessed by a Micro-computed tomography (micro-CT) scan and the expression of bone regeneration proteins by Western blot. Compared with the neat PCL group, PCL/npW scaffolds exhibited significantly increased cytocompatibility and osteogenic activity. This finding reveals a new concept for the design of a 3D-printed PCL/npW composite-based bone substitute for the early treatment of osteonecrosis defects. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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